Innovations in Nuclear Medicine Imaging for Reactive Oxygen Species: Applications and Radiopharmaceuticals

被引：0
作者：
Park, Joo Yeon [1 ]
Park, Sun Mi [1 ]
Lee, Tae Sup [2 ]
Lee, Sang Ju [3 ]
Kim, Ji-Young [4 ]
Oh, Seung Jun [3 ]
Yoon, Hai-Jeon [4 ]
Kim, Bom Sahn [1 ]
Moon, Byung Seok [1 ]
机构：
[1] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Nucl Med, Seoul 07804, South Korea
[2] Korea Inst Radiol & Med Sci, Div RI Applicat, Seoul 01812, South Korea
[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Nucl Med, Seoul 05505, South Korea
[4] Ewha Womans Univ, Mokdong Hosp, Coll Med, Dept Nucl Med, Seoul 07985, South Korea
来源：
ANTIOXIDANTS | 2024年 / 13卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
reactive oxygen species; nuclear medicine; radiopharmaceutical; positron emission tomography; single photon emission computed tomography; oxidative stress; INDUCED CARDIOTOXICITY; ACID; RADIOTRACER; SUPEROXIDE; PROBES;
D O I：
10.3390/antiox13101254
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Reactive oxygen species (ROS) are generated during normal cellular energy production and play a critical role in maintaining cellular function. However, excessive ROS can damage cells and tissues, contributing to the development of diseases such as cardiovascular, inflammatory, and neurodegenerative disorders. This review explores the potential of nuclear medicine imaging techniques for detecting ROS and evaluates various radiopharmaceuticals used in these applications. Radiopharmaceuticals, which are drugs labeled with radionuclides, can bind to specific biomarkers, facilitating their identification in vivo using nuclear medicine equipment, i.e., positron emission tomography and single photon emission computed tomography, for diagnostic purposes. This review includes a comprehensive search of PubMed, covering radiopharmaceuticals such as analogs of fluorescent probes and antioxidant vitamin C, and biomarkers targeting mitochondrial complex I or cystine/glutamate transporter.
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页数：18
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