In Vitro Evaluation of Electrospun PCL Bioscaffold with Zinc-Doped Bioactive Glass Powder Addition

被引：1

作者：

Chen, Ya-Yi ^{[1
,2
,3
]}

Chiou, Yuh-Jing ^{[3
,4
]}

Chang, Pei-Jung ^{[3
,5
]}

Chang, Wei-Min ^{[3
,6
]}

Yeh, Yu-Cheng ^{[7
]}

Chen, Chin-Yi ^{[3
,7
]}

Chang, Yu-Kang ^{[3
,8
,9
,10
]}

Lin, Chung-Kwei ^{[3
,11
,12
]}

机构：

[1] Natl Chung Hsing Univ, Doctoral Program Med Biotechnol, Taichung 402, Taiwan

[2] Tungs Taichung Metro Harbor Hosp, Dept Stomatol, Taichung 435, Taiwan

[3] Taipei Med Univ, Coll Oral Med, Res Ctr Digital Oral Sci & Technol, Taipei 110, Taiwan

[4] Tatung Univ, Dept Chem Engn & Biotechnol, Taipei 104, Taiwan

[5] Natl Taipei Univ Technol, Grad Inst Mfg Technol, Taipei 106, Taiwan

[6] Taipei Med Univ, Coll Oral Med, Sch Oral Hyg, Taipei 110, Taiwan

[7] Feng Chia Univ, Dept Mat Sci & Engn, Taichung 407, Taiwan

[8] Tungs Taichung Metro Harbor Hosp, Dept Cardiol, Taichung 435, Taiwan

[9] Natl Chung Hsing Univ, Coll Med, Dept Postbaccalaureate Med, Taichung 407, Taiwan

[10] Jenteh Jr Coll Med Nursing & Management, Dept Nursing, Miaoli 356, Taiwan

[11] Taipei Med Univ, Coll Oral Med, Sch Dent Technol, Taipei 110, Taiwan

[12] Natl Taipei Univ Technol, Addit Mfg Ctr Mass Customizat Prod, Taipei 106, Taiwan

来源：

POLYMERS | 2024年 / 16卷 / 19期

关键词：

PCL; zinc-doped bioactive glass; electrospinning; bioscaffold; bioactivity; antibacterial performance; FIBERS; NANOPARTICLES;

D O I：

10.3390/polym16192811

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Preparing electrospun fibers by applying a potential difference between a polymeric solution and a contacting substrate is increasingly attracting attention in tissue engineering applications. Among the numerous polymers, polycaprolactone (PCL) bioscaffold has been widely investigated due to its biocompatibility and biodegradability. Bioactive powder can be added to further improve its performance. In the present study, bioactive glass powder modified by adding 0-6 wt.% antibacterial zinc element (coded as ZBG) was prepared through the sol-gel process. Furthermore, PCL bioscaffolds with various ZBG additions were prepared using the electrospinning technique. The zinc-doped bioactive glass powder and electrospun PCL/ZBG bioscaffolds were evaluated using scanning electron microscopy, X-ray diffraction and Fourier-transform infrared spectroscopy to determine their structural properties. Additionally, in vitro bioactivity, biocompatibility and antibacterial performance were investigated. Experimental results showed that sol-gelled ZBG powder possessed superior bioactivity and 0.8 g ZBG was the optimal addition to prepare PCL/ZBG bioscaffolds with. All the electrospun PCL/ZBG bioscaffolds were biocompatible and their antibacterial performance against two S. aureus strains (SA133 and Newman) improved with increasing zinc concentration. Electrospun PCL/ZBG bioscaffolds exhibited excellent bioactivity and have great potential for biomedical application.

引用

页数：13

共 38 条

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