Background and Objective: The role of urine cytology during follow-up for low-grade (LG) non-muscle-invasive bladder cancer (NMIBC) is not well established, although cytology has low sensitivity in detecting LG recurrences. Our study aims to evaluate the impact of urine cytology as a complementary method to cystoscopy during follow-up for LG NMIBC. Methods: Patients diagnosed with primary LG TaT1 bladder cancer (BC) between 2010 and 2020 were included. Patients were stratified according to the EAU NMIBC scoring model. Urine cytology was performed during follow-up cystoscopy. The outcomes of the study were BC recurrence and upgrading to high-grade (HG). Cytology utility was established by assessing whether its result led to management change. Results: We included 337 patients with LG TaT1 BC. EAU risk group distribution was low in 262 (77.7%), intermediate in 57 (16.9%), and high-risk in 18 (5.3%) cases. With a median follow-up of 5 years, 166 (49.3%) patients experienced recurrence. Cystoscopy was positive in 154 (92.8%) and suspicious in 12 (7.2%) cases. Urine cytology was positive in 33 (19.9%) cases but only changed management in 3 (0.89%), all with suspicious cystoscopy. Positive cytology at first recurrence was associated with higher risk of upgrading during follow-up (HR 2.781, p = 0.006) and lower upgrading-free survival (p = 0.001). Conclusions: The role of urine cytology to detect first recurrences during follow-up for primary LG TaT1 NMIBC might be limited to patients with non-conclusive lesions in the cystoscopy. A positive cytology at first recurrence is associated with a higher risk of upgrading to HG BC during follow-up.
机构:
Loyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Barkan, Guliz A.
Wojcik, Eva M.
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Loyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Wojcik, Eva M.
Nayar, Ritu
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Northwestern Mem Hosp, Dept Pathol, Chicago, IL 60611 USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Nayar, Ritu
Savic-Prince, Spasenija
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Univ Basel Hosp, Inst Pathol, Basel, SwitzerlandLoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Savic-Prince, Spasenija
Quek, Marcus L.
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Loyola Univ Hlth Syst, Dept Urol, Maywood, IL USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Quek, Marcus L.
Kurtycz, Daniel F. I.
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Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin State Lab Hyg, Dept Pathol & Lab Med, Madison, WI USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Kurtycz, Daniel F. I.
Rosenthal, Dorothy L.
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Johns Hopkins Univ, Dept Pathol, Baltimore, MD USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
机构:
Loyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Barkan, Guliz A.
Wojcik, Eva M.
论文数: 0引用数: 0
h-index: 0
机构:
Loyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Wojcik, Eva M.
Nayar, Ritu
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Mem Hosp, Dept Pathol, Chicago, IL 60611 USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Nayar, Ritu
Savic-Prince, Spasenija
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h-index: 0
机构:
Univ Basel Hosp, Inst Pathol, Basel, SwitzerlandLoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Savic-Prince, Spasenija
Quek, Marcus L.
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h-index: 0
机构:
Loyola Univ Hlth Syst, Dept Urol, Maywood, IL USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Quek, Marcus L.
Kurtycz, Daniel F. I.
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h-index: 0
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Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin State Lab Hyg, Dept Pathol & Lab Med, Madison, WI USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA
Kurtycz, Daniel F. I.
Rosenthal, Dorothy L.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Dept Pathol, Baltimore, MD USALoyola Univ Healthcare Syst, Dept Pathol, 2160 S First Ave,Bldg 110,Room 2238, Maywood, IL 60153 USA