Circular RNAs in Cardiovascular Diseases: Molecular Mechanisms, Therapeutic Advances, and Innovations

被引:0
|
作者
Yuan, Zheng [1 ]
Huang, Shaoyuan [2 ]
Jin, Xin [2 ]
Li, Shanshan [2 ]
机构
[1] China Univ Petr, Coll Sci, Beijing 102249, Peoples R China
[2] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China
关键词
circRNA; cardiovascular diseases; synthetic circRNA sponges; RNA delivery systems; LIPID NANOPARTICLES; DRUG-DELIVERY; INJURY; HEART; TRANSLATION; ACTIVATION; THERAPIES; VECTORS; ROLES; RISK;
D O I
10.3390/genes15111423
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Circular RNAs (circRNAs) have emerged as promising therapeutic targets due to their unique covalently closed-loop structures and their regulatory roles in gene expression. Despite their potential, challenges in circRNA-based therapies include ensuring stability, tissue specificity, and efficient intracellular delivery. This review explores the implications of circRNAs in cardiovascular diseases (CVDs), providing an overview of their biogenesis, molecular mechanisms, and roles in disease pathology. In addition to discussing molecular features, this review highlights therapeutic advances, including small-molecule drugs targeting circRNAs, synthetic circRNA sponges, and innovations in drug delivery systems that enhance the effectiveness of these therapies. Finally, current challenges and future directions are addressed, emphasizing the need for continued research to fully unlock the therapeutic potential of circRNA-based strategies in cardiovascular medicine.
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页数:17
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