Unraveling brain aging through the lens of oral microbiota

被引：4
作者：
Hu, Qinchao [1 ,2 ]
Wang, Si [3 ,4 ,5 ]
Zhang, Weiqi [6 ,8 ,9 ,10 ]
Qu, Jing [7 ,8 ,9 ,10 ,11 ,12 ]
Liu, Guang-Hui [1 ,3 ,4 ,5 ,8 ,9 ,10 ,12 ]
机构：
[1] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China
[2] Sun Yat sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou, Guangdong, Peoples R China
[3] Capital Med Univ, Xuanwu Hosp, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
[4] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China
[5] Capital Med Univ, Beijing Municipal Geriatr Med Res Ctr Hosp, Aging Translat Med Ctr, Int Ctr Aging & Canc,Xuanwu Hosp, Beijing, Peoples R China
[6] Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing, Peoples R China
[7] China Natl Ctr Bioinformat, Beijing, Peoples R China
[8] Univ Chinese Acad Sci, Beijing, Peoples R China
[9] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China
[10] Aging Biomarker Consortium, Beijing, Peoples R China
[11] Chinese Acad Sci, State Key Lab Stem Cell & Reprod Biol, Inst Zool, Beijing, Peoples R China
[12] Beijing Inst Stem Cell & Regenerat Med, Beijing, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2025年 / 20卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; brain aging; multiple sclerosis; neurodegeneration; neurodegenerative diseases; oral microbiota; Parkinson's disease; periodontitis; bacteria; Porphyromonas gingivalis; HERPES-SIMPLEX-VIRUS; CHRONIC SYSTEMIC EXPOSURE; ALZHEIMERS-DISEASE; PORPHYROMONAS-GINGIVALIS; CATHEPSIN-B; COGNITIVE IMPAIRMENT; BEHAVIORAL DEFICITS; PARKINSONS-DISEASE; BARRIER BREAKDOWN; FUNGAL-INFECTION;
D O I：
10.4103/NRR.NRR-D-23-01761
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The oral cavity is a complex physiological community encompassing a wide range of microorganisms. Dysbiosis of oral microbiota can lead to various oral infectious diseases, such as periodontitis and tooth decay, and even affect systemic health, including brain aging and neurodegenerative diseases. Recent studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration, indicating potential avenues for intervention strategies. In this review, we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases, and dissect potential mechanisms by which oral microbes contribute to brain aging and neurodegeneration. We also highlight advances in therapeutic development grounded in the realm of oral microbes, with the goal of advancing brain health and promoting healthy aging.
引用
收藏
页码：1930 / 1943
页数：14
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