Two New Triterpenoid Saponins with Antifungal Activity from Camellia sinensis Flowers

被引：1
作者：
Zong, Jian-Fa [1 ]
Hong, Zhi-Bo [1 ]
Hu, Zi-Hui [1 ]
Hou, Ru-Yan [1 ]
机构：
[1] Anhui Agr Univ, Joint Res Ctr Food Nutr & Hlth IHM, Natl Key Lab Tea Plant Germplasm Innovat & Resourc, Anhui Prov Key Lab Food Safety Monitoring & Qual C, Hefei 230036, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 03期
关键词：
triterpenoid saponins; camsinsaponins; <italic>Camellia sinensis</italic>; antifungal; <italic>Candida</italic>; OLEIFERA ABEL; OLIGOGLYCOSIDES;
D O I：
10.3390/ijms26031147
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new triterpenoid saponins, namely camsinsaponins A and B (1, 2), along with two known congeners (3, 4) were isolated from Camellia sinensis flowers. Their structures were determined by extensive spectroscopic data. All compounds were assessed for antifungal bioactivity against Candida albicans, Candida glabrata, and Candida tropicalis. Compounds 1-4 showed excellent inhibitory effects. Notably, in regard to compounds 1 and 2, their MIC values against C. albicans were close to those of the positive control, fluconazole. Furthermore, the inhibitory elements of compounds 1-4 on C. glabrata were better than those of fluconazole. The aforementioned findings offer valuable insights for future development of novel therapeutic strategies against drug-resistant infections.
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页数：9
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