Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex

被引:3
作者
Gangitano, Elena [1 ]
Scannapieco, Francesca [2 ]
Lubrano, Carla [1 ]
Gnessi, Lucio [1 ]
机构
[1] Sapienza Univ Rome, Dept Expt Med, I-00161 Rome, Italy
[2] Univ Laquila, Dept Clin Med Publ Hlth Life & Environm Sci, I-67100 Laquila, Italy
来源
LIVERS | 2024年 / 4卷 / 04期
关键词
testosterone; NAFLD; MASLD; hepatic steatosis; gender medicine; hypogonadism; hyperandrogenism; metabolic syndrome; FATTY LIVER-DISEASE; POLYCYSTIC-OVARY-SYNDROME; HORMONE-BINDING GLOBULIN; TUMOR-NECROSIS-FACTOR; BODY-MASS INDEX; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN; ANDROGEN EXCESS; DIABETES-MELLITUS;
D O I
10.3390/livers4040038
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatic steatosis is considered the hepatic manifestation of metabolic disorders. Its global prevalence is a growing public health concern, estimated to affect over 30% of the population. Steatosis is strictly linked to metabolic dysfunction, leading to the revised terminology of MASLD (metabolic dysfunction-associated steatotic liver disease). The disease often progresses in conjunction with metabolic syndrome components, significantly increasing cardiovascular and overall mortality risks. The interplay between sex hormones and metabolic dysfunction is crucial, with male hypogonadism and female hyperandrogenism exacerbating the risk and severity of hepatic steatosis. In men, testosterone deficiency is associated with increased visceral adiposity and insulin resistance, creating a vicious cycle of metabolic deterioration. Conversely, in women, hyperandrogenism, particularly in conditions like polycystic ovary syndrome, may lead to severe metabolic disturbances, including hepatic steatosis. Estrogen deficiency also contributes to central adiposity and metabolic syndrome. The aim of this paper is to discuss this complex sex-dimorphic relationship.
引用
收藏
页码:534 / 549
页数:16
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