Redbed soft rocks, widely distributed in China, are highly susceptible to weathering, disintegration, and strength reduction under environmental and engineering disturbances, posing critical challenges for slope stability. This study investigates the stability and failure mechanisms of high road-cut slopes in redbed regions under excavation, seismic, and rainfall conditions. Numerical simulations were conducted based on actual engineering sites, using the FLAC3D finite difference model to simulate conditions typical of these sites while incorporating realistic geological features such as weak interlayers and fluid-solid coupling effects. Results reveal that under excavation, the slope exhibits displacement discontinuities and stress concentration near weak interlayers. However, the safety factor of the redbed slope remains at 1.58 at this stage, suggesting that large-scale collapses or landslides are unlikely. Seismic loading amplifies displacements and accelerations, with the maximum deformation reaching a shear displacement of 0.81 m, observed in the upper sections of the redbed slope. Under prolonged rainfall, the slope experiences increased saturation and sliding along interlayer surfaces, driven by reduced shear strength. Combined influences of these factors highlight the vulnerability of redbed slopes to localized failure in weakly weathered zones, necessitating targeted reinforcement strategies. These findings provide a deeper understanding of redbed slope behavior under complex conditions, addressing key challenges in geotechnical and transportation infrastructure engineering.