Preparation of a metal-organic framework glass-based chiral stationary phase for HPLC enantiomer separation

被引：2
作者：
Yang, Han
Liang, Fu-Chang
Tang, Bo
Chen, Hai-Xiong
Fu, Si-Yun
Cai, Song-Liang
Zhang, Wei-Guang [1 ]
Fan, Jun
Zheng, Sheng-Run [1 ]
机构：
[1] South China Normal Univ, GDMPA Key Lab Proc Control & Qual Evaluat Chiral P, Guangzhou Key Lab Analyt Chem Biomed, Guangzhou 510006, Peoples R China
来源：
JOURNAL OF SOLID STATE CHEMISTRY | 2025年 / 346卷
关键词：
Chiral stationary phase; MOF glass; Chiral resolution; AMYLOSE;
D O I：
10.1016/j.jssc.2025.125252
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The development of a chiral stationary phase (CSP) based on new matrices is still necessary because of the rapid growth of new chiral drugs and the limitations of the silica gel matrix. For the first time, MOF glass agZIF-62 was used as a matrix to fabricate a chiral stationary phase (CSP) by coating cellulose-tris(3,5dimethylphenylcarbamate) (CDMPC). These MOF glass-based CSPs can separate various racemic compounds, including metalaxyl, epoxiconazole, TSO, cis-metconazole, and triticonazole with resolution values (Rs) ranging from 1.22 to 4.58 and separation factors (alpha) ranging from 1.8 to 6.79. In addition, the HPLC enantiomer separation performances of MOF glass-based and MOF crystal-based CSPs were compared.
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页数：6
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