Synthesis of cyclic peptide-based [2]rotaxanes via copper-catalyzed azide-alkyne cycloaddition

被引：0
|
作者：
Kurita, Taichi [1 ]
Numata, Keiji [1 ,2 ,3 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Mat Chem, Nishikyo Ku, Kyoto 6158510, Japan
[2] RIKEN, Biomacromol Res Team, Ctr Sustainable Resource Sci, 2-1 Hirosawa, Wako, Saitama 3510198, Japan
[3] Keio Univ, Inst Adv Biosci, Nipponkoku 403-1, Tsuruoka, Yamagata 9970017, Japan
来源：
POLYMER CHEMISTRY | 2025年 / 16卷 / 04期
关键词：
PSEUDO-PROLINES; BETA-PEPTIDES; CONSTRUCTION; INHIBITORS; STABILITY;
D O I：
10.1039/d4py01169d
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Cyclic peptide-based [2]rotaxanes were synthesized from cyclo(PG)4 and monocationic ammonium threads via copper-catalyzed azide-alkyne cycloaddition (CuAAC), achieving relatively high yields of up to 36%. Cyclic peptides that do not contain bulky side chains or amino acids that induce the formation of cis-amide bonds were found to be unsuitable for rotaxane synthesis. This innovative synthetic approach advances the development of multifunctional rotaxanes and opens new avenues for their applications in various fields.
引用
收藏
页码：409 / 414
页数：6
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