Identification of near full-length human pegivirus type 2 (HPgV-2) genomes in blood donor samples co-infected with hepatitis C virus (HCV)

被引：0

作者：

Ragupathy, Viswanath ^{[1
]}

Kelley, Kylan ^{[1
]}

Hewlett, Indira ^{[1
]}

机构：

[1] FDA, Ctr Biol Evaluat & Res, Div Emerging & Transfus Transmitted Dis, Lab Mol Virol, Silver Spring, MD 20852 USA

来源：

MICROBIOLOGY RESOURCE ANNOUNCEMENTS | 2025年 / 14卷 / 03期

关键词：

pegivirus; HPgV-2; metagenomics; hepatitis C virus; nanopore; PREVALENCE;

D O I：

10.1128/mra.01179-24

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human pegivirus (HPgV) identified from an HCV-infected plasma sample through nanopore metagenomics. The analysis revealed a nearly complete HPgV-2 genome. Phylogenetic analysis confirmed its classification within the HPgV-2 geno type, providing insights into viral co-infection dynamics. The metagenomics approach advances the understanding of viral diversity and supports the development of accurate diagnostics.

引用

页数：3

共 28 条

[1] Difference of Intrahost Dynamics of the Second Human Pegivirus and Hepatitis C Virus in HPgV-2/HCV- Coinfected Patients
Liang, Yuanhao
Hu, Fengyu
Fan, Hang
Li, Linghua
Wan, Zhengwei
Wang, Haiying
Shui, Jingwei
Zhou, Yuanping
Tong, Yigang
Cai, Weiping
Tang, Shixing
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 11
[2] A Novel Human Pegivirus, HPgV-2 (HHpgV-1), Is Tightly Associated With Hepatitis C Virus (HCV) Infection and HCV/Human Immunodeficiency Virus Type 1 Coinfection
Wang, Haiying
Wan, Zhengwei
Xu, Ru
Guan, Yujuan
Zhu, Naling
Li, Jianping
Xie, Zhiwei
Lu, Aiqi
Zhang, Fuchun
Fu, Yongshui
Tang, Shixing
CLINICAL INFECTIOUS DISEASES, 2018, 66 (01) : 29 - 35
[3] Infection of human pegivirus 2 (HPgV-2) is associated with hepatitis C virus but not hepatitis B virus infection in people who inject drugs
Shui, Jingwei
Liu, Wenpei
Liang, Yuanhao
Zhang, Jian
Wan, Zhengwei
Wang, Haiying
Qu, Xiaowang
Tang, Shixing
JOURNAL OF GENERAL VIROLOGY, 2019, 100 (06): : 968 - 974
[4] Genetic variability of human pegivirus type 1 (HPgV-1) among Congolese co-infected with hepatitis C virus in Brazzaville, Congo
Niama, Roch Fabien
Mayengue, Pembe Issamou
Nsoukoula, Bertivie Cendres Matongo
Koukouikila-Kossounda, Felix
Badzi, Cynthia Nkoua
Mandiangou, Aldi Fred
Louzolo, Igor
Fila-Fila, Grace Petula Urielle
Dossou-Yovo, Louis Regis
Angounda, Monic Brunel
IJID REGIONS, 2023, 7 : 191 - 192
[5] Pharmacodynamics and pharmacokinetics of hepatitis C virus (HCV) and pegylated interferon-alfa2b in human immunodeficiency virus (HIV)/HCV co-infected patients.
Golia, P
Powers, K
Dorante, G
Cunningham-Rundles, S
Ribeiro, R
Shata, MT
Perelson, AS
Talal, AH
HEPATOLOGY, 2003, 38 (04) : 345A - 345A
[6] Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination
Lole, KS
Bollinger, RC
Paranjape, RS
Gadkari, D
Kulkarni, SS
Novak, NG
Ingersoll, R
Sheppard, HW
Ray, SC
JOURNAL OF VIROLOGY, 1999, 73 (01) : 152 - 160
[7] You're Not the One: Treating Subjects Co-infected with Hepatitis C Genotypes 2 and 3 and Human Immunodeficiency Virus
Pearlman, Brian L.
Lim, Tanna H.
DIGESTIVE DISEASES AND SCIENCES, 2014, 59 (08) : 1681 - 1683
[8] You’re Not the One: Treating Subjects Co-infected with Hepatitis C Genotypes 2 and 3 and Human Immunodeficiency Virus
Brian L. Pearlman
Tanna H. Lim
Digestive Diseases and Sciences, 2014, 59 : 1681 - 1683
[9] Full-length core sequence dependent complex-type glycosylation of hepatitis C virus E2 glycoprotein
Zhu, LX
Liu, J
Li, YC
Kong, YY
Staib, C
Sutter, G
Wang, Y
Li, GD
WORLD JOURNAL OF GASTROENTEROLOGY, 2002, 8 (03) : 499 - 504
[10] Effect of IL-2 on hepatitis C virus RNA levels in patients co-infected with human immunodeficiency virus receiving HAART
Tedaldi, EM
Chen, L
Markowitz, N
Kelly, L
Abrams, D
JOURNAL OF VIRAL HEPATITIS, 2005, 12 (04) : 414 - 420

← 1 2 3 →