Review of the literature on the use of contrast-enhanced ultrasound (CEUS) in vascular malformations.

Introduction Vascular malformations (VascM) are difficult to diagnose and manage because of their heterogeneous presentations. Ultrasound represents the first imaging exam for patients with vascular malformations. In some cases, additional and sometimes functional imaging will be necessary to confirm the diagnosis or to highlight a vascular network of drainage. Doppler ultrasound could be not enough and a certain number of complementary examinations are then required. Contrast-enhanced ultrasound (CEUS) is used in current practice in the vascular field and in particular the monitoring of aortic stents.Method We present here the interest of using CEUS in VascM through a review of the literature. The search was carried out from Pubmed from 1975 to 2023 using the following keywords << vascular malformation >> and << contrast enhanced ultrasound >> / << venous malformation" and "contrast enhanced ultrasound"/ "venous malformation and contrast enhanced ultrasound".Results The first search found 887 articles. Among them, 124 articles were retained after the selection of the formats. After reading the abstracts, only 9 articles were retained due to the non-selection of articles dealing with other explorations or irrelevance, as they did not deal with vascular malformation. At the end, 17 articles were selected.Discussion and conclusion CEUS allows very usefull dynamic analysis of the perfusion in the diagnosis of VascM . CEUS with time analysis is a promising imaging method for the evaluation of perfusion before and after percutaneous treatment of vascular malformations. Area under the curve reduction indicates therapy-induced changes in perfusion. Nevertheless, CEUS is not yet a standardized test for diagnosing or characterizing peripheral vascular malformations. However, its safety allows it to be used for the diagnosis and even the follow up of the VascM. Unfortunately, we haven't been able to find any randomized studies comparing CESU with other techniques.