Transforming one organ into another to overcome challenges in tissue engineering

被引：3

作者：

Wang, Zhenzhen ^{[1
]}

Tian, Xuejiao ^{[1
]}

Wang, Chunming ^{[2
]}

Qi, Xiaolong ^{[3
]}

Gracia-Sancho, Jordi ^{[4
,5
]}

Dong, Lei ^{[1
,6
]}

机构：

[1] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China

[3] Lanzhou Univ, Inst Portal Hypertens, CHESS Ctr, Hosp 1, Lanzhou, Gansu, Peoples R China

[4] Univ Bern, Bern Univ Hosp, Dept Visceral Surg & Med, Inselspital, Hochschulstr 4, CH-3008 Bern, Switzerland

[5] CIBEREHD, IDIBAPS Res Inst, Liver Vasc Biol Res Grp, Barcelona, Spain

[6] Nanjing Univ, Chem & Biomed Innovat Ctr, Nanjing, Jiangsu, Peoples R China

来源：

PORTAL HYPERTENSION & CIRRHOSIS | 2022年 / 1卷 / 02期

基金：

瑞士国家科学基金会; 中国国家自然科学基金;

关键词：

blood vessel; immune rejection; organ transformation; spleen; tissue engineering; xenotransplantation; LIVER-TRANSPLANTATION; HEPATOCYTE TRANSPLANTATION; ISLET TRANSPLANTATION; REGENERATIVE MEDICINE; STEM-CELLS; SPLENECTOMY; SPLEEN; VASCULARIZATION; STRATEGIES; MORPHOLOGY;

D O I：

10.1002/poh2.26

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Tissue engineering (TE) is promising for the regeneration of failed organs. However, immune rejection, shortage of seed cells, and unintegrated blood vessels restrict the development and clinical application of TE. The last factor is the most challenging and intractable. Harnessing the mature blood vessel network in existing dispensable organs could be a powerful approach to effectively overcome the obstacles. After being remodeled to harbor an immunosuppressive and proregenerative niche, these potential target organs can be transformed into other organs with specific physiological functions, compensating the latter's failed native functions. Organ transformation, such as a hepatized spleen, represents an effective and encouraging TE strategy. In this review, we discuss the current development and obstacles of TE and its feasibility and superiority in organ transformation.

引用

页码：116 / 124

页数：9

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