The HCV-Melanoma Paradox: First Multi-Cohort and Molecular Net-Work Analysis Reveals Lower Incidence but Worse Outcomes-Integrating Clinical, Real-World, and In Silico Data

被引：0

作者：

Al Ageeli, Essam ^{[1
]}

Abdulhakim, Jawaher A. ^{[2
]}

Hussein, Mohammad H. ^{[3
]}

Alnoman, Maryam M. ^{[4
]}

Alkhalil, Samia S. ^{[5
]}

Issa, Peter P. ^{[6
]}

Nemr, Nader A. ^{[7
]}

Abdelmaksoud, Ahmed ^{[8
]}

Alenizi, Dhaifallah A. ^{[9
]}

Fawzy, Manal S. ^{[10
,11
]}

Toraih, Eman A. ^{[12
,13
]}

机构：

[1] Jazan Univ, Fac Med, Dept Basic Med Sci, Jazan 45141, Saudi Arabia

[2] Taibah Univ, Coll Appl Med Sci, Dept Med Lab, Yanbu 46423, Saudi Arabia

[3] Ochsner Clin Fdn, New Orleans, LA 70121 USA

[4] Taibah Univ, Fac Sci, Dept Biol, Yanbu 46423, Saudi Arabia

[5] Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra 11961, Saudi Arabia

[6] Louisiana State Univ, Hlth Sci Ctr, Sch Med, New Orleans, LA 70112 USA

[7] Suez Canal Univ, Fac Med, Endem & Infect Dis Dept, Ismailia 41522, Egypt

[8] Univ Calif Riverside, Dept Internal Med, Riverside, CA 92521 USA

[9] Northern Border Univ, Dept Med, Fac Med, Ar Ar 91431, Saudi Arabia

[10] Northern Border Univ, Fac Med, Dept Biochem, Ar Ar 1321, Saudi Arabia

[11] Northern Border Univ, Ctr Hlth Res, Ar Ar 91431, Saudi Arabia

[12] Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

[13] Suez Canal Univ, Dept Histol & Cell Biol, Genet Unit, Ismailia 41522, Egypt

来源：

MEDICINA-LITHUANIA | 2024年 / 60卷 / 09期

关键词：

HCV; melanoma; IPA; molecular markers; risk factors; prognosis; HEPATITIS-C VIRUS; INFECTION; INTERLEUKIN-6; CANCER; ERA;

D O I：

10.3390/medicina60091531

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Objectives: The relationship between hepatitis C virus (HCV) infection and melanoma remains poorly understood. This study aimed to investigate the association between HCV and melanoma, assess outcomes in patients with both conditions, and explore potential molecular mechanisms connecting the two diseases. Materials and Methods: We conducted a retrospective cohort study of 142 melanoma patients, including 29 with HCV-related cirrhosis, and analyzed their clinical outcomes. For external validation, we used the TriNetX Global Collaborative Network database, comprising 219,960 propensity-matched patients per group. An in silico analysis was performed to identify the molecular pathways linking HCV and melanoma. Results: In the retrospective cohort, HCV-positive melanoma patients showed an increased risk of early relapse (41.4% vs. 18.6%, p = 0.014), recurrence (65.5% vs. 39.8%, p = 0.020), and mortality (65.5% vs. 23.0%, p < 0.001) compared to HCV-negative patients. TriNetX data analysis revealed that HCV-positive patients had a 53% lower risk of developing melanoma (RR = 0.470, 95% CI: 0.443-0.498, p < 0.001). However, HCV-positive melanoma patients had higher all-cause mortality (HR = 1.360, 95% CI: 1.189-1.556, p < 0.001). An in silico analysis identified key molecular players, including IL-6 and CTLA4, in the HCV-melanoma network. Conclusions: While HCV infection may be associated with a lower risk of melanoma development, HCV-positive patients who develop melanoma have poorer outcomes. The identified molecular pathways provide potential targets for future research and therapeutic interventions.

引用

页数：21