Chiral Sodium Glycerophosphate Catalyst for Enantioselective Michael Reactions of Chalcones

被引：0

作者：

Ghigo, Giovanni ^{[1
]}

Rivella, Julia ^{[1
]}

Bose, Alessio Robiolio ^{[1
]}

Dughera, Stefano ^{[1
]}

机构：

[1] Univ Torino, Dept Chem, Via Pietro Giuria 7, I-10125 Turin, Italy

来源：

MOLECULES | 2024年 / 29卷 / 19期

关键词：

conjugate addition; organocatalyst; chiral catalyst; DENSITY FUNCTIONALS;

D O I：

10.3390/molecules29194763

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A chiral sodium glycerophosphate is successfully exploited as a catalyst in the Michael addition of methyl malonate to a number of chalcones. The reactions supplied the target adducts in satisfactory yields and good enantiomeric excesses. A tentative computational study is presented, aiming to understand the reaction mechanism.

引用

页数：7

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