Expression levels of ACE and ACE2 in the placenta and white adipose tissue of lean and obese pregnant women

被引：0
|
作者：
Guimaraes Junior, Orcione Ferreira [1 ]
de Oliveira, Gabriel Ledo Pereira [2 ]
Lelis, Deborah de Farias [1 ,3 ]
Baldo, Thais de Oliveira Faria [3 ]
Baldo, Marcelo Perim [1 ,3 ]
Santos, Sergio Henrique Sousa [1 ,4 ]
Andrade, Joao Marcus Oliveira [1 ,3 ,4 ]
机构：
[1] Univ Estadual Montes Claros Unimontes, State Univ Montes Claros, Grad Program Hlth Sci, Programa Pos Grad Ciencias Saude PPGCS, Campus Univ Prof Darcy Ribeiro,Av Prof Rui Braga S, BR-39401089 Montes Claros, MG, Brazil
[2] FASA, Stano Agostinho Coll Afya Educ, Fac Sanot Agostinho, Dept Med, Vitoria da Conquista, BA, Brazil
[3] Univ Estadual Montes Claros, Dept Pathophysiol, Montes Claros, MG, Brazil
[4] Univ Fed Minas Gerais UFMG, Fed Univ Minas Gerais, Grad Program Food & Hlth, Programa Pos Grad Alimentos & Saude PPGAS, Montes Claros, MG, Brazil
来源：
BIOMARKERS | 2024年 / 29卷 / 07期
关键词：
Maternal obesity; renin-angiotensin system; inflammation; adipose tissue; placenta; RENIN-ANGIOTENSIN SYSTEM; MATERNAL OBESITY; ALDOSTERONE SYSTEM; WEIGHT-GAIN; INFLAMMATION; RISK; DYSLIPIDEMIA; HYPERTENSION; INHIBITION; METABOLISM;
D O I：
10.1080/1354750X.2024.2411346
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
BackgroundThis study evaluated the expression of ACE and ACE2 in the placenta and white adipose tissue in lean and obese women, and correlated their levels with anthropometric, clinical, and laboratory parameters, and tissue count of inflammatory cells.MethodsA cross-sectional analytical study was performed with 49 pregnant women and their respective newborns. Samples of placenta and adipose tissue were used for measuring mRNA expression for ACE and ACE2 through qRT-PCR. Inflammatory cell counting was performed through conventional microscopy.ResultsAn increase in ACE expression and a decrease in ACE2 were observed in the placenta and adipose tissue of women with obesity. ACE2 levels showed a negative correlation with pre-pregnancy BMI and total cholesterol.ConclusionMaternal obesity can modulate the expression of RAS components in the placenta and white adipose tissue, with ACE2 correlated with pre-pregnancy BMI and total cholesterol.
引用
收藏
页码：434 / 441
页数：8
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