Immune-epithelial cell interactions in lung development, homeostasis and disease

被引：0

作者：

Yoshida, Masahiro ^{[1
,2
]}

Arzili, Romina ^{[1
]}

Nikolic, Marko Z. ^{[1
,3
]}

机构：

[1] UCL, Div Med, UCL Resp, London, England

[2] Jikei Univ, Sch Med, Dept Internal Med, Div Resp Dis, Tokyo, Japan

[3] Univ Coll London Hosp NHS Fdn Trust, London, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2025年 / 178卷

基金：

英国国家替代、减少和改良动物研究中心;

关键词：

Immune development; Lung epithelial development; Lung homeostasis and repair; Epithelium; Immune-epithelial crosstalk; ALVEOLAR MACROPHAGES; PULMONARY-FIBROSIS; INTERFERON-GAMMA; TYPE-2; IMMUNITY; T-CELLS; EXPRESSION; SURFACTANT; MICE; REGENERATION; ACTIVATION;

D O I：

10.1016/j.biocel.2024.106703

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The importance of the crosstalk between lung epithelial and immune cells, which emerges from early development and lasts throughout life, is corroborated by a growing body of scientific evidence. This communication not only has a role in driving lung morphogenesis during development, but it is also required in adulthood for the maintenance of homeostasis and repair following infection or injury. Disruption of the intricate immuneepithelial crosstalk can lead to diseases such as COPD and IPF. In this review we summarise the current knowledge regarding the communication between various immune and epithelial cells in development, homeostasis, regeneration and disease, while identifying the current gaps in our knowledge required to facilitate the development of more effective therapies.

引用

页数：7

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