Effect of Medication and Freezing of Gait on Rambling and Trembling in Quiet Standing in Individuals With Parkinson's Disease

被引:0
作者
Cupertino, Layla [1 ]
Bersotti, Felipe Marrese [2 ]
Novaes, Thayna Magalhaes [1 ]
Mochizuki, Luis [2 ]
Shokur, Solaiman [3 ,4 ,5 ]
Bouri, Mohamed [3 ]
Barbieri, Fabio Augusto [6 ]
Coelho, Daniel Boari [1 ,7 ,8 ]
机构
[1] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, SP, Brazil
[2] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, SP, Brazil
[3] Ecole Polytech Fed Lausanne, Lausanne, Switzerland
[4] Scuola Super Sant Anna, BioRobot Inst, Pisa, Italy
[5] Scuola Super Sant Anna, Dept Excellence Robot & AI, Pisa, Italy
[6] Sao Paulo State Univ Unesp, Fac Sci, Dept Phys Educ, Human Movement Res Lab MOVI LAB, Bauru, SP, Brazil
[7] Fed Univ ABC, Biomed Engn, Sao Bernardo Do Campo, SP, Brazil
[8] Fed Univ ABC UFABC, Ctr Engn Modeling & Appl Social Sci CECS, Sao Bernardo Do Campo, SP, Brazil
关键词
movement disorders; biomechanics; somatosensory information; center of pressure; POSTURAL CONTROL; STEP INITIATION; SWAY; CEREBELLAR; COMPONENTS; LEVODOPA; BALANCE; STATE; TASKS;
D O I
10.1123/mc.2024-0063
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Individuals with Parkinson's disease (PD) with freezing of gait (FoG) exhibit difficulty with changes in sensory input, indicating a potential sensorimotor integration deficit. Understanding how levodopa impacts balance particularly in FoG, is critical. As traditional postural sway measures may not fully capture the complexity of balance control, rambling and trembling decomposition of the center of pressure allows a more detailed assessment of postural control by distinguishing between supraspinal and spinal contributions, offering insights into sensorimotor integration deficits. This study aims to analyze the effects of medication and FoG on rambling and trembling in quiet standing in individuals with PD. Methods: We analyzed 13 individuals with PD with FoG (PD freezers) and 19 individuals with PD without FoG (PD nonfreezers) while quiet standing on a rigid and malleable surface under (ON) and without (OFF) dopaminergic medication. Area, root mean square, and mean velocity were calculated for rambling and trembling trajectory. Results: For the rambling, all variables were significantly higher on the malleable compared with the rigid surface. For trembling, (a) all variables were higher on the malleable compared with the rigid surface (p<.001), and (b) area and medial-lateral root mean square were significantly higher ON compared with OFF medication for both groups of participants similarly. Conclusion: Our results strengthen the evidence that PD freezers have the same postural sway in quiet posture as PD nonfreezers, using similar mechanisms to control the posture. In addition, levodopa influences spinal mechanisms more than supraspinal ones in individuals with PD in quiet standing.
引用
收藏
页码:202 / 214
页数:13
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