Emerging Nanomedicine Approaches in Targeted Lung Cancer Treatment

被引：1

作者：

Alexandru, Isaic ^{[1
]}

Davidescu, Lavinia ^{[2
]}

Motofelea, Alexandru Catalin ^{[3
]}

Ciocarlie, Tudor ^{[4
]}

Motofelea, Nadica ^{[5
]}

Costachescu, Dan ^{[6
]}

Marc, Monica Steluta ^{[7
]}

Suppini, Noemi ^{[7
]}

Sovrea, Alina Simona ^{[8
]}

Coseriu, Razvan-Lucian ^{[9
]}

Bondor, Daniela-Andreea ^{[10
]}

Bobeica, Laura-Gabriela ^{[10
]}

Crintea, Andreea ^{[10
]}

机构：

[1] Victor Babes Univ Med & Pharm, Dept Gen Surh 10, Timisoara 300041, Romania

[2] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania

[3] Victor Babes Univ Med & Pharm, Fac Med, Dept Internal Med, Timisoara 300041, Romania

[4] Victor Babes Univ Med & Pharm, Dept Internal Med 7 2, Discipline Cardiol, Timisoara 300041, Romania

[5] Victor Babes Univ Med & Pharm, Dept Obstet & Gynecol, Eftimie Murgu Sq 2, Timisoara 300041, Romania

[6] Victor Babes Univ Med & Pharm, Radiol Dept, Timisoara 300041, Romania

[7] Victor Babes Univ Med & Pharm Timisoara, Discipline Pulmonol, Timisoara 300041, Romania

[8] Iuliu Hatieganu Univ Med & Pharm, Dept Morphol Sci, Cluj Napoca 400349, Romania

[9] Univ Med Pharm Sci & Technol George Emil Palade, Dept Microbiol, Targu Mures 540142, Romania

[10] Iuliu Hatieganu Univ Med & Pharm, Dept Med Biochem, Cluj Napoca 400012, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 20期

关键词：

lung cancer; nanomedicine; nanoparticles; VEGF; VEGFR; GRAPHENE QUANTUM DOTS; DRUG-DELIVERY SYSTEMS; ANTI-VEGF SIRNA; THERANOSTIC LIPOSOMES; 1ST-LINE TREATMENT; CO-DELIVERY; PHASE-III; RECEPTOR; CXCR4; ACTIVATION;

D O I：

10.3390/ijms252011235

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung cancer, the leading cause of cancer-related deaths worldwide, is characterized by its aggressive nature and poor prognosis. As traditional chemotherapy has the disadvantage of non-specificity, nanomedicine offers innovative approaches for targeted therapy, particularly through the development of nanoparticles that can deliver therapeutic agents directly to cancer cells, minimizing systemic toxicity and enhancing treatment efficacy. VEGF and VEGFR are shown to be responsible for activating different signaling cascades, which will ultimately enhance tumor development, angiogenesis, and metastasis. By inhibiting VEGF and VEGFR signaling pathways, these nanotherapeutics can effectively disrupt tumor angiogenesis and proliferation. This review highlights recent advancements in nanoparticle design, including lipid-based, polymeric, and inorganic nanoparticles, and their clinical implications in improving lung cancer outcomes, exploring the role of nanomedicine in lung cancer diagnoses and treatment.

引用

页数：19

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