The gamma-glutamyl transpeptidase to platelet ratio: a good noninvasive biomarker for predicting for the occurrence and prognosis of patients with hepatitis E virus-related acute liver failure

被引：0

作者：

Zhu, Shuai ^{[1
]}

Yuan, Jun ^{[2
]}

Ju, Feng ^{[3
]}

Gu, Mengmeng ^{[4
]}

Xiang, Ze ^{[5
]}

Zhang, Yan ^{[6
]}

机构：

[1] Soochow Univ, Peoples Hosp Suzhou 5, Affiliated Infect Dis Hosp, Dept Clin Lab,Suzhou Med Coll, Suzhou, Peoples R China

[2] First Peoples Hosp Yancheng City, Dept Lab Med, Yancheng, Peoples R China

[3] Yangzhou Univ, Jianhu Clin Coll, Dept Lab Med, Jianhu, Peoples R China

[4] Nanjing Med Univ, Affiliated Suzhou Hosp, Suzhou Municipal Hosp, Gusu Sch,Dept Clin Lab, Suzhou, Peoples R China

[5] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China

[6] Suzhou Yongding Hosp, Dept Clin Lab, Suzhou, Peoples R China

来源：

FRONTIERS IN MEDICINE | 2025年 / 12卷

关键词：

hepatitis E; acute liver failure; gamma-glutamyl transpeptidase to platelet ratio (GPR); diagnosis; prognosis; FIBROSIS;

D O I：

10.3389/fmed.2025.1573114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The relationship between GPR and hepatitis E has not been reported. This study evaluates the GPR levels in AHE patients and HEV-ALF patients and explores the role of GPR levels in the prognosis of HEV-ALF patients, offering new strategies and methods for the diagnosis and prognosis of HEV-ALF patients. Methods Serum samples were collected from 206 AHE patients and 217 HEV-ALF patients admitted to the First Affiliated Hospital of Zhejiang University School of Medicine, Suzhou Yongding Hospital, and Nanjing Medical University Affiliated Suzhou Hospital between January 1, 2017, and November 30, 2024. Results The GPR level in the HEV-ALF group was significantly higher than in the AHE group (p < 0.001). OPLS-DA analysis revealed that INR, TBIL, PLT, GPR, TCH, ALT, AFP, TP, ALB, and AST were the major influential factors for the occurrence of HEV-ALF. GPR showed good diagnostic performance with an AUC of 0.701. DCA further supported the utility of GPR across a range of threshold probabilities. Regarding the prediction of 30-day mortality, GPR levels were significantly higher in the non-survival group compared to the survival group (p < 0.001). OPLS-DA analysis highlighted GPR as the most influential factor for predicting 30-day mortality. GPR demonstrated an AUC of 0.703. DCA results also indicated GPR's strong decision-making ability for predicting 30-day mortality in HEV-ALF patients. Conclusion GPR is highly expressed in HEV-ALF patients and is closely related to their prognosis.

引用

页数：7

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