Mitigating infections in implantable urological continence devices: risks, challenges, solutions, and future innovations. A comprehensive literature review

被引:0
作者
Yang, Bob [1 ,2 ]
Lavigne, Axelle [1 ]
Carugo, Dario [2 ]
Turney, Ben [2 ]
Somani, Bhaskar [3 ]
Stride, Eleanor [2 ]
机构
[1] Royal Berkshire NHS Fdn Trust, Reading, England
[2] Univ Oxford, Oxford, England
[3] Univ Hosp Southampton, NHS Fdn Trust, Southampton, England
基金
英国工程与自然科学研究理事会;
关键词
biofilms; diagnostics; incontinence; infection; prosthesis; treatments; ARTIFICIAL URINARY SPHINCTER; SURGICAL SITE INFECTIONS; LONG-TERM DURABILITY; MALE SYSTEM ATOMS; POSTPROSTATECTOMY-INCONTINENCE; POSTOPERATIVE COMPLICATIONS; ANTIMICROBIAL-PROPHYLAXIS; SMOKING-CESSATION; PENILE PROSTHESIS; NITRIC-OXIDE;
D O I
10.1097/MOU.0000000000001208
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose of reviewStress urinary incontinence is a growing issue in ageing men, often following treatment for prostate cancer or bladder outflow obstruction. While implantable urological devices offer relief, infections are a significant concern. These infections can lead to device removal, negating the benefits and impacting patient outcomes. This review explores the risks and factors contributing to these infections and existing strategies to minimize them. These strategies encompass a multifaceted approach that considers patient-specific issues, environmental issues, device design and surgical techniques. However, despite these interventions, there is still a pressing need for further advancements in device infection prevention.Recent findingsFaster diagnostics, such as Raman spectroscopy, could enable early detection of infections. Additionally, biocompatible adjuncts like ultrasound-responsive microbubbles hold promise for enhanced drug delivery and biofilm disruption, particularly important as antibiotic resistance rises worldwide.SummaryBy combining advancements in diagnostics, device design, and patient-specific surgical techniques, we can create a future where implantable urological devices offer men a significant improvement in quality of life with minimal infection risk.
引用
收藏
页码:495 / 508
页数:14
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