Association of Low Muscle Strength With Incident Pneumonia in Older Patients With Heart Failure

被引：0

作者：

Yamaguchi, Kenta ^{[1
,2
,3
]}

Konishi, Masaaki ^{[2
,3
]}

Kagiyama, Nobuyuki ^{[4
,5
,6
]}

Kasai, Takatoshi ^{[7
,8
]}

Kamiya, Kentaro ^{[9
,10
]}

Saito, Hiroshi ^{[11
]}

Saito, Kazuya ^{[12
]}

Maekawa, Emi ^{[13
]}

Kitai, Takeshi ^{[14
]}

Iwata, Kentaro ^{[15
]}

Jujo, Kentaro ^{[16
]}

Wada, Hiroshi ^{[17
]}

Shinoda, Satoru ^{[18
]}

Akiyama, Eiichi ^{[2
,3
]}

Momomura, Shin-Ichi ^{[19
]}

Hibi, Kiyoshi ^{[2
,3
]}

Matsue, Yuya ^{[7
]}

机构：

[1] Yokosuka City Hosp, Dept Cardiovasc Med, Yokosuka, Japan

[2] Yokohama City Univ, Grad Sch Med, Dept Cardiol, Yokohama, Japan

[3] Yokohama City Univ, Div Cardiol, Div Cardiol, Med Ctr, Yokohama, Japan

[4] Juntendo Univ, Dept Cardiovasc Biol & Med, Dept Digital Hlth & Telemed R&D, Tokyo, Japan

[5] Juntendo Univ, Grad Sch Med, Tokyo, Japan

[6] Sakakibara Heart Inst Okayama, Dept Cardiol, Okayama, Japan

[7] Juntendo Univ, Grad Sch Med, Dept Cardiovasc Biol & Med, Tokyo, Japan

[8] Juntendo Univ, Grad Sch Med, Cardiovasc Resp Sleep Med, Tokyo, Japan

[9] Kitasato Univ, Grad Sch Med Sci, Dept Rehabil Sci, Sagamihara, Japan

[10] Kitasato Univ, Sch Allied Hlth Sci, Dept Rehabil, Sagamihara, Japan

[11] Kameda Med Ctr, Dept Rehabil, Kamogawa, Japan

[12] Sakakibara Heart Inst Okayama, Dept Rehabil, Okayama, Japan

[13] Kitasato Univ, Sch Med, Dept Cardiovasc Med, Sagamihara, Japan

[14] Natl Cerebral & Cardiovasc Ctr, Dept Cardiovasc Med, Suita, Japan

[15] Kobe City Med Ctr Gen Hosp, Dept Rehabil, Kobe, Japan

[16] Nishiarai Heart Ctr Hosp, Dept Cardiol, Tokyo, Japan

[17] Kobe City Med Ctr Gen Hosp, Dept Cardiovasc Med, Kobe, Japan

[18] Yokohama City Univ, Sch Med, Dept Biostat, Yokohama, Japan

[19] Saitama Citizens Med Ctr, Saitama, Japan

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2024年 / 80卷 / 01期

关键词：

Cardiovascular disease; Mortality; Skeletal muscle; COMMUNITY-ACQUIRED PNEUMONIA; RISK; EPIDEMIOLOGY; IMPUTATION; SARCOPENIA; SURVIVAL; ADULTS; MODEL;

D O I：

10.1093/gerona/glae266

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: Patients with heart failure (HF) are at an increased risk of developing pneumonia, leading to a high mortality. A decrease in muscle strength due to aging or concomitant disease may contribute to the development of pneumonia in older adults. We sought to investigate the relationship between low muscle strength and pneumonia incidence in older patients hospitalized for worsening HF. Methods: We carried out a subanalysis of the FRAGILE-HF, a prospective multicenter observational study, including 1 266 consecutive older (>= 65 years) patients hospitalized with HF (mean age 80.2 +/- 7.8 years; 57.4% male; left ventricular ejection fraction 46% +/- 17%) and information of incident pneumonia observed after discharge. Patients were followed up for 2 years post-discharge. Results: A total of 88 patients (7.0%) developed pneumonia after discharge, with an incidence of 42.7 per 1 000 person-years. A total of 893 patients with low muscle strength, defined as handgrip strength <28 kg for men and <18 kg for women according to international criteria, were more likely to develop pneumonia than those with normal muscle strength (p < .001; log-rank test). Low muscle strength was a significant predictor of incident pneumonia (adjusted hazard ratio with 95% confidence interval: 2.65 [1.31-5.35], p = .007). Furthermore, the mortality rates were 43.2% in patients who developed pneumonia and 19.3% in those who did not, indicating a heightened risk of death following the onset of pneumonia (adjusted hazard ratio: 4.25 [2.91-6.19], p < .001). Conclusions: In older patients hospitalized for HF, low muscle strength was associated with incident pneumonia after discharge.

引用

页数：8

共 41 条

[1]

Abbafati C, 2020, LANCET, V396, P1204

[2] PRACTICAL PROBLEMS IN FITTING A PROPORTIONAL HAZARDS MODEL TO DATA WITH UPDATED MEASUREMENTS OF THE COVARIATES [J].