Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren's Disease

被引：0
作者：
Zhu, Wen [1 ]
Lu, Yun [1 ]
Zhu, Yifan [1 ]
Huang, Xiaohan [1 ]
Wang, Yue [1 ]
Wang, Yue [1 ]
机构：
[1] Nanjing Univ Chinese Med, Affiliated Hosp, Dept Rheumatol & Immunol, Nanjing 210032, Jiangsu, Peoples R China
来源：
JOURNAL OF INFLAMMATION RESEARCH | 2025年 / 18卷
基金：
中国国家自然科学基金;
关键词：
Sj & ouml; gren's disease; pattern recognition receptor; salivary gland epithelial cell; immune homeostasis; innate immune; PRIMARY SJOGRENS-SYNDROME; DYSFUNCTION; IMMUNITY; SERUM;
D O I：
10.2147/JIR.S509220
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sj & ouml;gren's disease, an autoimmune inflammatory disease, currently lacks effective treatment options. The salivary gland, a crucial exocrine organ responsible for saliva production and local immune responses on mucous membranes, is frequently impaired in individuals with Sj & ouml;gren's disease. Restoring salivary gland function poses a significant challenge for researchers. Salivary epithelial cells, recognized as pivotal components of the salivary gland, have been increasingly implicated as key initiators of inflammation and exhibit innate immune cell-like properties. On the whole, SGEC plays a protective role in the physiological state, and can also participate in the persistence of inflammation as an initiating factor in the pathological state. In the review, we explore the interplay between Ca+, endoplasmic reticulum (ER), and mitochondrial homeostasis imbalance in salivary epithelial cells. Additionally, we provide an overview of current literature on research advancements related to Pattern Recognition Receptors (PRRs), programmed cell death, posttranslational modification (PTM), and oral microecology, etc. specifically focusing on their implications in salivary epithelial cells. Given the crucial role of salivary gland epithelial cells in the onset of Sj & ouml;gren's disease, a treatment based on salivary gland epithelial cells may have the potential to alleviate the condition by addressing the inflammatory response in the salivary glands.
引用
收藏
页码：3039 / 3053
页数：15
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