A crosstalk between autophagy and apoptosis in intracerebral hemorrhage

被引：3

作者：

Wang, Moyan ^{[1
]}

Chen, Xin ^{[1
]}

Li, Shuangyang ^{[1
]}

Wang, Lingxue ^{[1
]}

Tang, Hongmei ^{[1
]}

Pu, Yuting ^{[1
]}

Zhang, Dechou ^{[1
,2
]}

Fang, Bangjiang ^{[1
,3
]}

Bai, Xue ^{[1
,2
]}

机构：

[1] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Dept Neurol, Natl Tradit Chinese Med Clin Res Base, Luzhou, Peoples R China

[2] Southwest Med Univ, Inst Integrated Chinese & Western Med, Luzhou, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Dept Emergency, Longhua Hosp, Shanghai, Peoples R China

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2024年 / 18卷

关键词：

autophagy; apoptosis; cerebral hemorrhage; Bcl-2; Bax; EXPERIMENTAL SUBARACHNOID HEMORRHAGE; EARLY BRAIN-INJURY; PROSURVIVAL BCL-2 PROTEINS; RATS POSSIBLE INVOLVEMENT; NEURONAL CELL APOPTOSIS; BECLIN; ISCHEMIC-STROKE; JNK1-MEDIATED PHOSPHORYLATION; CEREBRAL-ISCHEMIA; MEDIATED CLEAVAGE;

D O I：

10.3389/fncel.2024.1445919

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracerebral hemorrhage (ICH) is a severe condition that devastatingly harms human health and poses a financial burden on families and society. Bcl-2 Associated X-protein (Bax) and B-cell lymphoma 2 (Bcl-2) are two classic apoptotic markers post-ICH. Beclin 1 offers a competitive architecture with that of Bax, both playing a vital role in autophagy. However, the interaction between Beclin 1 and Bcl-2/Bax has not been conjunctively analyzed. This review aims to examine the crosstalk between autophagy and apoptosis in ICH by focusing on the interaction and balance of Beclin 1, Bax, and Bcl-2. We also explored the therapeutic potential of Western conventional medicine and traditional Chinese medicine (TCM) in ICH via controlling the crosstalk between autophagy and apoptosis.

引用

页数：16

共 177 条

[21] DRAM, a p53-induced modulator of autophagy, is critical for apoptosis [J].

Crighton, Diane ;

Wilkinson, Simon ;

O'Prey, Jim ;

Syed, Nelofer ;

Smith, Paul ;

Harrison, Paul R. ;

Gasco, Milena ;

Garrone, Ornella ;

Crook, Tim ;

Ryan, Kevin M. .

CELL, 2006, 126 (01) :121-134

[22] Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats [J].

Dai, Shuhui ;

Hua, Ya ;

Keep, Richard F. ;

Novakovic, Nemanja ;

Fei, Zhou ;

Xi, Guohua .

NEUROBIOLOGY OF DISEASE, 2019, 126 :76-84

[23] Cell death: Critical control points [J].

Danial, NN ;

Korsmeyer, SJ .

CELL, 2004, 116 (02) :205-219

[24] Suppressive role of lovastatin in intracerebral hemorrhage through repression of autophagy [J].

Deng, Xiong ;

Yang, Jinmei ;

Qing, Ruqi ;

Yuan, Heying ;

Yue, Pinhua ;

Tian, Song .

METABOLIC BRAIN DISEASE, 2023, 38 (01) :361-372

[25] Primary and Secondary Prevention of Ischemic Stroke and Cerebral Hemorrhage [J].

Diener, Hans-Christoph ;

Hankey, Graeme J. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (15) :1804-1818

[26] Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease [J].

Dong, Yan ;

Chen, Hengwen ;

Gao, Jialiang ;

Liu, Yongmei ;

Li, Jun ;

Wang, Jie .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2019, 136 :27-41

[27]

Duan SR, 2020, DRUG DES DEV THER, V14, P3143, DOI [10.2147/DDDT.S255828, 10.2147/DDDT.S255628]

[28] Roles of autophagy and endoplasmic reticulum stress in intracerebral hemorrhage-induced secondary brain injury inrats [J].

Duan, Xiao-Chun ;

Wang, Wei ;

Feng, Dong-Xia ;

Yin, Jia ;

Zuo, Gang ;

Chen, Dong-Dong ;

Chen, Zhou-Qing ;

Li, Hai-Ying ;

Wang, Zhong ;

Chen, Gang .

CNS NEUROSCIENCE & THERAPEUTICS, 2017, 23 (07) :554-566

[29] Alpha-synuclein's degradation in vivo Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease [J].

Ebrahimi-Fakhari, Darius ;

McLean, Pamela J. ;

Unni, Vivek K. .

AUTOPHAGY, 2012, 8 (02) :281-283

[30]

Fang L., 2019, Chin. J. Cancer Biother, V26, P1203, DOI [10.3872/j.issn.1007-385x.2019.11.004, DOI 10.3872/J.ISSN.1007-385X.2019.11.004]

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