A crosstalk between autophagy and apoptosis in intracerebral hemorrhage

被引：0
作者：
Wang, Moyan [1 ]
Chen, Xin [1 ]
Li, Shuangyang [1 ]
Wang, Lingxue [1 ]
Tang, Hongmei [1 ]
Pu, Yuting [1 ]
Zhang, Dechou [1 ,2 ]
Fang, Bangjiang [1 ,3 ]
Bai, Xue [1 ,2 ]
机构：
[1] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Dept Neurol, Natl Tradit Chinese Med Clin Res Base, Luzhou, Peoples R China
[2] Southwest Med Univ, Inst Integrated Chinese & Western Med, Luzhou, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Dept Emergency, Longhua Hosp, Shanghai, Peoples R China
来源：
FRONTIERS IN CELLULAR NEUROSCIENCE | 2024年 / 18卷
关键词：
autophagy; apoptosis; cerebral hemorrhage; Bcl-2; Bax; EXPERIMENTAL SUBARACHNOID HEMORRHAGE; EARLY BRAIN-INJURY; PROSURVIVAL BCL-2 PROTEINS; RATS POSSIBLE INVOLVEMENT; NEURONAL CELL APOPTOSIS; BECLIN; ISCHEMIC-STROKE; JNK1-MEDIATED PHOSPHORYLATION; CEREBRAL-ISCHEMIA; MEDIATED CLEAVAGE;
D O I：
10.3389/fncel.2024.1445919
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intracerebral hemorrhage (ICH) is a severe condition that devastatingly harms human health and poses a financial burden on families and society. Bcl-2 Associated X-protein (Bax) and B-cell lymphoma 2 (Bcl-2) are two classic apoptotic markers post-ICH. Beclin 1 offers a competitive architecture with that of Bax, both playing a vital role in autophagy. However, the interaction between Beclin 1 and Bcl-2/Bax has not been conjunctively analyzed. This review aims to examine the crosstalk between autophagy and apoptosis in ICH by focusing on the interaction and balance of Beclin 1, Bax, and Bcl-2. We also explored the therapeutic potential of Western conventional medicine and traditional Chinese medicine (TCM) in ICH via controlling the crosstalk between autophagy and apoptosis.
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页数：16
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