Exploring Bioinformatics Tools to Analyze the Role of CDC6 in the Progression of Polycystic Ovary Syndrome to Endometrial Cancer by Promoting Immune Infiltration

被引：0

作者：

Song, Yuhang ^{[1
,2
]}

Zhang, Jing ^{[3
]}

Li, Yao ^{[1
]}

Cheng, Lufeng ^{[4
]}

Song, Hua ^{[2
]}

Zhang, Yuhang ^{[2
]}

Du, Guoqing ^{[1
]}

Yu, Sunyue ^{[2
]}

Zou, Yizhou ^{[3
]}

Xu, Qi ^{[1
]}

机构：

[1] Xinjiang Med Univ, Sch Basic Med, Urumqi 830054, Peoples R China

[2] Xinjiang Med Univ, Sch Clin Med, Urumqi 830054, Peoples R China

[3] Cent South Univ, Sch Basic Med, Dept Immunol, Changsha 410017, Peoples R China

[4] Xinjiang Med Univ, Basic Med Coll, Urumqi 830054, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 23期

基金：

中国国家自然科学基金;

关键词：

CDC6; polycystic ovarian syndrome; endometrial cancer; immune infiltration; ONCOGENE-INDUCED SENESCENCE; DNA-REPLICATION; UP-REGULATION; THERAPEUTIC TARGET; BREAST-CANCER; RISK; WOMEN; MUTATIONS; NEOPLASIA; STRESS;

D O I：

10.3390/ijms252312974

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell division cycle 6 (CDC6) is essential for the initiation of DNA replication in eukaryotic cells and contributes to the development of various human tumors. Polycystic ovarian syndrome (PCOS) is a reproductive endocrine disease in women of childbearing age, with a significant risk of endometrial cancer (EC). However, the role of CDC6 in the progression of PCOS to EC is unclear. Therefore, we examined CDC6 expression in patients with PCOS and EC. We evaluated the relationship between CDC6 expression and its prognostic value, potential biological functions, and immune infiltrates in patients with EC. In vitro analyses were performed to investigate the effects of CDC6 knockdown on EC proliferation, migration, invasion, and apoptosis. CDC6 expression was significantly upregulated in patients with PCOS and EC. Moreover, this protein caused EC by promoting the aberrant infiltration of macrophages into the immune microenvironment in patients with PCOS. A functional enrichment analysis revealed that CDC6 exerted its pro-cancer and pro-immune cell infiltration functions via the PI3K-AKT pathway. Moreover, it promoted EC proliferation, migration, and invasion but inhibited apoptosis. This protein significantly reduced EC survival when mutated. These findings demonstrate that CDC6 regulates the progression of PCOS to EC and promotes immune infiltration.

引用

页数：25

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