Oligomerization of STING and Chemical Regulatory Strategies

被引：0
作者：
Chen, Xi [2 ]
Zhuo, Shao-Hua [1 ]
Li, Yan-Mei [1 ,3 ,4 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Zhili Coll, Beijing 100084, Peoples R China
[3] Beijing Inst Brain Disorders, Beijing 100084, Peoples R China
[4] Tsinghua Univ, Ctr Synthet & Syst Biol, Beijing 100084, Peoples R China
来源：
CHEMBIOCHEM | 2025年
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
STING; Oligomerization; Agonist; Chemical strategy; Pocket-independent; MUTATION; ACTIVATION; ADAPTER; DISEASE; PALMITOYLATION; INFLAMMATION; STIMULATOR; DISCOVERY; VACCINES; REVEALS;
D O I：
10.1002/cbic.202400888
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stimulator of interferon genes (STING) plays a crucial role in innate immunity. Upon the recognition of cytosolic dsDNA, STING undergoes several structural changes, with oligomerization playing a key role in initiating a cascade of immune responses. Therefore, controlling the STING pathway by manipulating STING oligomerization is a practical strategy. This review focuses on the detailed mechanism of STING oligomerization, highlighting its decisive role. It also describes oligomerization-based strategies to regulate STING protein, such as the use of small-molecule agonists and biomacromolecules, highlighting their interaction modes and potential therapeutic applications. This knowledge may lead to the development of innovative approaches for treating cancer and immune disorders.
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页数：12
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共 73 条
  • [1] Corrales L., Glickman L.H., McWhirter S.M., Kanne D.B., Sivick K.E., Katibah G.E., Woo S.R., Lemmens E., Banda T., Leong J.J., Metchette K., Dubensky T.W., Gajewski T.F., Cell Rep., 11, pp. 1018-1030, (2015)
  • [2] Barber G.N., Nature, 15, pp. 760-770, (2015)
  • [3] Garland K.M., Sheehy T.L., Wilson J.T., Chem. Rev., 122, pp. 5977-6039, (2022)
  • [4] Zhang Z., Zhou H., Ouyang X., Dong Y., Sarapultsev A., Luo S., Hu D., Signal Transduct Target Ther., 7, pp. 394-422, (2022)
  • [5] Ishikawa H., Barber G.N., Nature, 455, pp. 674-678, (2008)
  • [6] Jin L., Waterman P.M., Jonscher K.R., Short C.M., Reisdorph N.A., Cambier J.C., Mol. Cell. Biol., 28, pp. 5014-5026, (2008)
  • [7] Zhong B., Yang Y., Li S., Wang Y.-Y., Li Y., Diao F., Lei C., He X., Zhang L., Tien P., Shu H.-B., Immunity, 29, pp. 538-550, (2008)
  • [8] Sun W., Li Y., Chen L., Chen H., You F., Zhou X., Zhou Y., Zhai Z., Chen D., Jiang Z., Proc. Natl. Acad. Sci. USA, 106, pp. 8653-8658, (2009)
  • [9] Ergun S.L., Fernandez D., Weiss T.M., Li L., Cell, 178, pp. 290-301, (2019)
  • [10] Shang G., Zhang C., Chen Z.J., Bai X.-C., Zhang X., Nature, 567, pp. 389-393, (2019)
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