McArdle sign and neck flexion-induced change in central motor conduction in multiple sclerosis

被引：0

作者：

Hoffman, E. Matthew ^{[2
]}

Brown, Lucille ^{[3
]}

Jolliffe, Evan ^{[2
,4
]}

Sechi, Elia ^{[5
]}

Harmsen, William S. ^{[6
]}

Schilaty, Nathan D. ^{[7
,8
]}

Weinshenker, Brian G. ^{[1
,2
]}

机构：

[1] Univ Virginia, Dept Neurol, POB 800394,McKim Hall, Charlottesville, VA 22908 USA

[2] Mayo Clin, Dept Neurol, Rochester, MN USA

[3] Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA

[4] Riddiford Med Dept Neurol, Wellington, New Zealand

[5] Univ Sassari, Dept Med Surg & Expt Sci, Neurol Unit, Sassari, Italy

[6] Mayo Clin, Dept Quantitat Hlth Serv, Rochester, MN USA

[7] Univ S Florida, Dept Neurosurg & Brain Repair, Tampa, FL USA

[8] Univ S Florida, Ctr Neuromusculoskeletal Res, Tampa, FL USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2024年 / 30卷 / 14期

关键词：

Multiple sclerosis; McArdle sign; demyelination; electrophysiology; evoked potentials; motor; TRANSCRANIAL MAGNETIC STIMULATION; DISABILITY;

D O I：

10.1177/13524585241295868

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Rapidly reversible weakness with neck flexion (McArdle sign) is common in patients with multiple sclerosis (MS). The pathophysiology is unknown.Objective: To evaluate changes in central motor conduction time (CMCT) in patients with and without McArdle sign.Methods: We measured McArdle sign with a torque cell and CMCT with neck flexed and extended in patients with MS, other causes of myelopathy, and healthy controls.Results: CMCT was prolonged with neck flexion disproportionately in those with MS-associated myelopathy (MSAM) with prominent McArdle sign compared to MS patients with lesser degrees of McArdle sign, and to controls.Conclusion: McArdle sign may result from stretch-induced slowing of conduction due to demyelination.

引用

页码：1830 / 1834

页数：5

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