IL-12 family cytokines and autoimmune diseases: A potential therapeutic target?

被引：2

作者：

Cui, Xiaoyu ^{[1
,2
]}

Liu, Wu ^{[1
]}

Jiang, Hanxue ^{[1
]}

Zhao, Qihan ^{[1
,2
]}

Hu, Yuehong ^{[1
,2
]}

Tang, Xinyue ^{[1
,2
]}

Liu, Xianli

Dai, Haoran ^{[1
,4
]}

Rui, Hongliang ^{[1
,3
]}

Liu, Baoli ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing 100010, Peoples R China

[2] Capital Med Univ, Lab Clin Med, Beijing 100069, Peoples R China

[3] Beijing Inst Chinese Med, Beijing 100010, Peoples R China

[4] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Shunyi Branch, Beijing 100310, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY | 2025年 / 10卷

基金：

中国国家自然科学基金;

关键词：

Autoimmune diseases; Cytokine; IL-12; IL-23; IL-35; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACTIVE PSORIATIC-ARTHRITIS; INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; COLLAGEN-INDUCED ARTHRITIS; STIMULATORY FACTOR NKSF; BIOLOGIC-NAIVE PATIENTS; DOUBLE-BLIND; B-CELL;

D O I：

10.1016/j.jtauto.2024.100263

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, the discovery of IL-12 family cytokines, which includes IL-12, IL-23, IL-27, IL-35, and IL-39, whose biological functions directly or indirectly affect various autoimmune diseases. In autoimmune diseases, IL-12 family cytokines are aberrantly expressed to varying degrees. These cytokines utilize shared subunits to influence T-cell activation and differentiation, thereby regulating the balance of T-cell subsets, which profoundly impacts the onset and progression of autoimmune diseases. In such conditions, IL-12 family members are aberrantly expressed to varying degrees. By exploring their immunomodulatory functions, researchers have identified varying therapeutic potentials for each member. This review examines the physiological functions of the major IL-12 family members and their interactions, discusses their roles in several autoimmune diseases, and summarizes the progress of clinical studies involving monoclonal antibodies targeting IL-12 and IL-23 subunits currently available for treatment.

引用

页数：20

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