IL-12 family cytokines and autoimmune diseases: A potential therapeutic target?

被引：2

作者：

Cui, Xiaoyu ^{[1
,2
]}

Liu, Wu ^{[1
]}

Jiang, Hanxue ^{[1
]}

Zhao, Qihan ^{[1
,2
]}

Hu, Yuehong ^{[1
,2
]}

Tang, Xinyue ^{[1
,2
]}

Liu, Xianli

Dai, Haoran ^{[1
,4
]}

Rui, Hongliang ^{[1
,3
]}

Liu, Baoli ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing 100010, Peoples R China

[2] Capital Med Univ, Lab Clin Med, Beijing 100069, Peoples R China

[3] Beijing Inst Chinese Med, Beijing 100010, Peoples R China

[4] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Shunyi Branch, Beijing 100310, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY | 2025年 / 10卷

基金：

中国国家自然科学基金;

关键词：

Autoimmune diseases; Cytokine; IL-12; IL-23; IL-35; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACTIVE PSORIATIC-ARTHRITIS; INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; COLLAGEN-INDUCED ARTHRITIS; STIMULATORY FACTOR NKSF; BIOLOGIC-NAIVE PATIENTS; DOUBLE-BLIND; B-CELL;

D O I：

10.1016/j.jtauto.2024.100263

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, the discovery of IL-12 family cytokines, which includes IL-12, IL-23, IL-27, IL-35, and IL-39, whose biological functions directly or indirectly affect various autoimmune diseases. In autoimmune diseases, IL-12 family cytokines are aberrantly expressed to varying degrees. These cytokines utilize shared subunits to influence T-cell activation and differentiation, thereby regulating the balance of T-cell subsets, which profoundly impacts the onset and progression of autoimmune diseases. In such conditions, IL-12 family members are aberrantly expressed to varying degrees. By exploring their immunomodulatory functions, researchers have identified varying therapeutic potentials for each member. This review examines the physiological functions of the major IL-12 family members and their interactions, discusses their roles in several autoimmune diseases, and summarizes the progress of clinical studies involving monoclonal antibodies targeting IL-12 and IL-23 subunits currently available for treatment.

引用

页数：20

共 227 条

[1] Pharmacokinetics and Exposure Response Relationships of Ustekinumab in Patients With Crohn's Disease [J].

Adedokun, Omoniyi J. ;

Xu, Zhenhua ;

Gasink, Christopher ;

Jacobstein, Douglas ;

Szapary, Philippe ;

Johanns, Jewel ;

Gao, Long-Long ;

Davis, Hugh M. ;

Hanauer, Stephen B. ;

Feagan, Brian G. ;

Ghosh, Subrata ;

Sandborn, William J. .

GASTROENTEROLOGY, 2018, 154 (06) :1660-1671

[2] Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 [J].

Aggarwal, S ;

Ghilardi, N ;

Xie, MH ;

de Sauvage, FJ ;

Gurney, AL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1910-1914

[3] Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection [J].

Altare, F ;

Lammas, D ;

Revy, P ;

Jouanguy, E ;

Döffinger, R ;

Lamhamedi, S ;

Drysdale, P ;

Scheel-Toellner, D ;

Girdlestone, J ;

Darbyshire, P ;

Wadhwa, M ;

Dockrell, H ;

Salmon, M ;

Fischer, A ;

Durandy, A ;

Casanova, JL ;

Kumararatne, DS .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (12) :2035-2040

[4]

Alwan W, 2015, CLIN EXP RHEUMATOL, V33, pS2

[5] Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature [J].

Andrews, Caroline ;

McLean, Mairi H. ;

Durum, Scott K. .

INFLAMMATORY BOWEL DISEASES, 2016, 22 (09) :2255-2264

[6] Serum levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17 and IL-18 in patients with active psoriasis and correlation with disease severity [J].

Arican, O ;

Aral, M ;

Sasmaz, S ;

Ciragil, P .

MEDIATORS OF INFLAMMATION, 2005, (05) :273-279

[7] Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation [J].

Ayoglu, Burcu ;

Donato, Michele ;

Furst, Daniel E. ;

Crofford, Leslie J. ;

Goldmuntz, Ellen ;

Keyes-Elstein, Lynette ;

James, Judith ;

Macwana, Susan ;

Mayes, Maureen D. ;

McSweeney, Peter ;

Nash, Richard A. ;

Sullivan, Keith M. ;

Welch, Beverly ;

Pinckney, Ashley ;

Mao, Rong ;

Chung, Lorinda ;

Khatri, Purvesh ;

Utz, Paul J. .

ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 (05) :670-680

[8] Cytokines and mucosa! immunity [J].

Bamias, Giorgos ;

Arseneau, Kristen O. ;

Cominelli, Fabio .

CURRENT OPINION IN GASTROENTEROLOGY, 2014, 30 (06) :547-552

[9] Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

[10] Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells [J].

Becker, C ;

Wirtz, S ;

Blessing, M ;

Pirhonen, J ;

Strand, D ;

Bechthold, O ;

Frick, J ;

Galle, PR ;

Autenrieth, I ;

Neurath, MF .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (05) :693-706

← 1 2 3 4 5 6 7 8 9 10 →