Relationship Between Human Microbiome and Helicobacter pylori

被引:1
作者
La Placa, Giada [1 ]
Covino, Marcello [2 ]
Candelli, Marcello [2 ]
Gasbarrini, Antonio [3 ]
Franceschi, Francesco [2 ]
Merra, Giuseppe [4 ]
机构
[1] Univ Roma Tor Vergata, Ph D Sch Appl Med Surg Sci, I-00133 Rome, Italy
[2] Univ Cattolica Sacro Cuore, A Gemelli Gen Hosp Fdn IRCCS, Dept Emergency Med, I-00135 Rome, Italy
[3] Univ Cattolica Sacro Cuore, A Gemelli Gen Hosp Fdn IRCCS, Dept Med & Surg Sci, I-00135 Rome, Italy
[4] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy
关键词
human microbiota; Helicobacter pylori; gut; gastric; genome; ORAL MICROBIOTA; GUT MICROBIOME; DISEASE; HEALTH; ASSOCIATION; PREVALENCE; INFECTION; GASTRITIS;
D O I
10.3390/microbiolres16010024
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The enteric microbiota influences gene expression in the colonic epithelium. H. pylori (Helicobacter pylori) affects gastric growth factors, cytokines, and tumor cell markers, potentially benefiting the host. The interaction between H. pylori and human microbiota is complex but appears beneficial in gastric disease development. This publication discusses the human microbiota, gastric microbiome, chronic H. pylori colonization, and the bacterium's role in gastric disease. The interplay between the gastric bacterium and human microbiota during infection is also explored. The human gut has the most abundant and complex microbial community and performs vital roles in food digestion and nutrient uptake, extraction of absorbable vitamins, and inhibition of pathogen colonization. Helicobacter pylori is a highly specialized human gastric pathogen, predominantly colonizing the gastric mucus layer, on or adherent to the underlying gastric epithelial cell surfaces. Many studies have suggested that the gastric microbiome is related to H. pylori infection, and some bacterial species can be used for the detection or diagnosis of H. pylori infection. Human microbiome and genome analysis has revolutionized our understanding of the intricate relationship between humans and their associated microbial communities. The integration of microbiome data has displayed promising capabilities in occult disease detection, unveiling previously hidden pathologies and providing opportunities for early intervention. These groundbreaking discoveries have paved the way for novel therapeutic strategies and a deeper comprehension of the interconnected nature of the human microbiome and overall health.
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页数:20
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