Preclinical Testing Strategies for Epilepsy Therapy Development

被引:0
作者
Riley, Victoria A. [1 ,2 ]
Danzer, Steve C. [1 ,2 ,3 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Dept Anesthesia, Cincinnati, OH USA
[2] Cincinnati Childrens Hosp Med Ctr, Neurosci Res Ctr, Cincinnati, OH USA
[3] Univ Cincinnati, Dept Anesthesiol, Cincinnati, OH USA
关键词
biomarkers; epileptogenesis; disease-modifying therapy; antiepileptogenic; epilepsy; mTOR; tuberous sclerosis; TUBEROUS SCLEROSIS; STATUS EPILEPTICUS; MAMMALIAN TARGET; MODEL; SEIZURES; EVEROLIMUS; PROGRESSION; INHIBITION; DAMAGE;
D O I
10.1177/15357597241292197
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The development of antiepileptogenic and disease-modifying treatments for epilepsy is a key goal of epilepsy research. Technological and scientific advances over the past two decades have seen the development of numerous therapeutic approaches, many of which show great promise in animal models. To facilitate and de-risk the translation of these promising approaches, however, rigorous preclinical testing is needed. For the present review, we discuss challenges and approaches to conduct preclinical testing of antiepileptogenic and disease-modifying treatments in animal models.
引用
收藏
页码:51 / 57
页数:7
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