Lymph node yield independently predicts local recurrence in papillary thyroid cancer

被引:0
作者
Yang, Zihao M. [1 ]
Papachristos, Alexander [1 ,2 ]
Gill, Anthony J. [1 ,3 ,4 ]
Aniss, Ahmad M. [1 ,2 ]
Sywak, Mark [1 ,2 ]
Sidhu, Stan [1 ,2 ]
机构
[1] Univ Sydney, Sydney Med Sch, Fac Med & Hlth, Northern Clin Sch, Sydney, NSW, Australia
[2] Royal North Shore Hosp, Endocrine Surg Unit, Sydney, NSW 2065, Australia
[3] Royal North Shore Hosp, NSW Hlth Pathol, Dept Anat Pathol, Sydney, NSW, Australia
[4] Royal North Shore Hosp, Kolling Inst Med Res, Canc Diag & Pathol Grp, Sydney, NSW, Australia
关键词
lymph node ratio; lymph node yield; papillary thyroid cancer; recurrence; surgical outcomes; NECK DISSECTION; PROGNOSTIC IMPLICATIONS; LATERAL NECK; RATIO; CARCINOMA; SURVIVAL; IMPACT; METASTASIS;
D O I
10.1002/wjs.12395
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: Lymph node yield (LNY) is a validated quality control parameter in colorectal cancer surgery, with >12 nodes reflecting an adequate oncological resection. No formal guidelines exist in the context of central and lateral compartment lymph node dissection for papillary thyroid cancer (PTC). This study aimed to investigate the association between LNY and regional recurrence in PTC patients, and to define a threshold LNY that indicates adequate compartmental lymphadenectomy. Methods: A retrospective analysis of patient data (1992-2022) was conducted using "The University of Sydney Endocrine Surgery Unit" database. Patients undergoing either prophylactic or therapeutic dissection of the central compartment or therapeutic dissection of the lateral compartment for PTC were included. Multivariate logistic regression analysis was performed to examine the relationship between nodal yield and local recurrence. Results: On multivariate analysis, a central LNY <= 3 was an independent adverse prognostic factor for central recurrence (odds ratios [OR] 2.19, 95% confidence intervals [CI] 1.15-4.17, and p = 0.018) and a lateral LNY <= 20 was independently predictive of lateral recurrence (OR 2.45, 95% CI 1.24-5.31, and p = 0.007). Conclusions: This study highlights the association between LNY and local recurrence in PTC. Our findings suggest that minimum LNY thresholds (>3 for central and >20 for lateral) may serve as indicators of adequate dissection. Further research should validate these findings across healthcare centers.
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收藏
页码:131 / 137
页数:7
相关论文
共 34 条
  • [1] What Are Thyroidectomy Patients Really Concerned About?
    Abdul-Sater, Lara
    Henry, Melissa
    Majdan, Agnieszka
    Mijovic, Tamara
    Franklin, Jason H.
    Brandt, Michael G.
    Black, Martin J.
    Hier, Michael P.
    Payne, Richard J.
    [J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2011, 144 (05) : 685 - 690
  • [2] Beal SH, 2010, AM SURGEON, V76, P28
  • [3] Prognostic Significance of Metastatic Lymph Node Ratio in Patients with pN3 Gastric Cancer Who Underwent Curative Gastrectomy
    Bilici, Ahmet
    Selcukbiricik, Fatih
    Seker, Mesut
    Oven, Basak B.
    Olmez, Omer Fatih
    Yildiz, Ozcan
    Olmuscelik, Oktay
    Hamdard, Jamshid
    Acikgoz, Ozgur
    Cakir, Asli
    Kapran, Yersu
    Balik, Emre
    Oncel, Mustafa
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2019, 42 (04) : 204 - 211
  • [4] Incidence and Risk Factors for Occult Level 3 Lymph Node Metastases in Papillary Thyroid Cancer
    Fraser, Sheila
    Zaidi, Nisar
    Norlen, Olov
    Glover, Anthony
    Kruijff, Schelto
    Sywak, Mark
    Delbridge, Leigh
    Sidhu, Stan B.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2016, 23 (11) : 3587 - 3592
  • [5] The role of prophylactic central compartment lymph node dissection in elderly patients with differentiated thyroid cancer: a multicentric study
    Gambardella, Claudio
    Patrone, Renato
    Di Capua, Francesco
    Offi, Chiara
    Mauriello, Claudio
    Clarizia, Guglielmo
    Andretta, Claudia
    Polistena, Andrea
    Sanguinetti, Alessandro
    Calo, Pietrogiorgio
    Docimo, Giovanni
    Avenia, Nicola
    Conzo, Giovanni
    [J]. BMC SURGERY, 2019, 18 (Suppl 1)
  • [6] Prognostic Implications of Lymph Node Yield in Central and Lateral Neck Dissections for Well-Differentiated Papillary Thyroid Carcinoma
    Heaton, Chase M.
    Chang, Jolie L.
    Orloff, Lisa A.
    [J]. THYROID, 2016, 26 (03) : 434 - 440
  • [7] The extent of lymph node yield in central neck dissection can be affected by preoperative and intraoperative assessment and alter the prognosis of papillary thyroid carcinoma
    Hu, Jia-Qian
    Wen, Duo
    Ma, Ben
    Zhang, Ting-Ting
    Liao, Tian
    Shi, Xiao
    Wang, Yu-Long
    Zhu, Yong-Xue
    Wang, Yu
    Wei, Wen-Jun
    Ji, Qing-Hai
    [J]. CANCER MEDICINE, 2020, 9 (03): : 1017 - 1024
  • [8] Thyroid Carcinoma: Phenotypic Features, Underlying Biology and Potential Relevance for Targeting Therapy
    Hu, Jinwei
    Yuan, Isabella J.
    Mirshahidi, Saied
    Simental, Alfred
    Lee, Steve C.
    Yuan, Xiangpeng
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (04) : 1 - 25
  • [9] Hwang Jinseok, 2022, Korean J Clin Oncol, V18, P27, DOI 10.14216/kjco.22004
  • [10] A Retrospective Study of Lymph Node Yield in Lateral Neck Dissection for Papillary Thyroid Carcinoma
    Issa, Khalil
    Stevens, Madelyn N.
    Sun, Yuhui
    Thomas, Samantha
    Collins, Alissa
    Cohen, Jonathan
    Esclamado, Ramon M.
    Rocke, Daniel J.
    [J]. ENT-EAR NOSE & THROAT JOURNAL, 2022, 101 (07) : 456 - 462