The Effect of Body Composition on Osteoporosis Risk in Adults with Celiac Disease

被引：1

作者：

Skoracka, Kinga ^{[1
,2
]}

Michalak, Michal ^{[3
]}

Ratajczak-Pawlowska, Alicja Ewa ^{[1
,4
]}

Rychter, Anna Maria ^{[1
,4
]}

Zawada, Agnieszka ^{[1
]}

Dobrowolska, Agnieszka ^{[1
]}

Krela-Kazmierczak, Iwona ^{[1
,4
]}

机构：

[1] Poznan Univ Med Sci, Dept Gastroenterol Dietet & Internal Dis, PL-60356 Poznan, Poland

[2] Poznan Univ Med Sci, Doctoral Sch, PL-60812 Poznan, Poland

[3] Poznan Univ Med Sci, Dept Comp Sci & Stat, PL-60806 Poznan, Poland

[4] Poznan Univ Med Sci, Dept Gastroenterol Dietet & Internal Dis, Lab Nutrigenet, PL-60356 Poznan, Poland

来源：

GASTROENTEROLOGY INSIGHTS | 2024年 / 15卷 / 04期

关键词：

celiac disease; bioimpedance analysis; osteoporosis; dual-energy X-ray absorptiometry; body composition; BONE-MINERAL DENSITY; EPIDEMIOLOGY;

D O I：

10.3390/gastroent15040062

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Celiac disease (CD) has been linked with increased susceptibility to osteoporosis; therefore, we aimed to explore whether, in a group of patients with CD, body composition parameters impact bone parameters. Methods: This study covered 56 adults-47 women and 9 men-with CD, and 20 healthy controls-16 women and 4 men. Densitometry of the lumbar spine (L1-L4) and femoral neck (FN) was conducted using dual-energy X-ray absorptiometry (DXA). Body mass was measured by bioimpedance method. Furthermore, serum 25(OH)D and ionized calcium concentration were determined. Results: We found osteopenia in the FN in 19.65% of patients and in L1-L4 in 26.79% of the patients. One patient displayed evidence of osteoporosis in the L1-L4 region, while two patients (3.57%) exhibited similar findings in the FN. Significant positive correlations were observed between bone mineral density (BMD) and body mass, fat-free mass (FFM), muscle mass, and basal metabolic rate (BMR) for both L1-L4 and the FN, and body mass index (BMI) of L1-L4. Conclusions: In conclusion, people with CD are at an increased risk of decreased BMD. Patients with lower body mass, FFM, muscle mass, BMI, and BMR more often present with osteopenia and osteoporosis.

引用

页码：895 / 903

页数：9

共 27 条

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