Photoredox Radical Cyclization of o-Vinylaryl Isocyanides and Aryldiazonium Tetrafluoroborates for the Synthesis of 2,4-Disubstituted Quinolines

被引：0

作者：

Gao, Mei-Jin ^{[1
]}

Ding, Chuan ^{[1
]}

Huang, Peng-Fei ^{[1
]}

Xie, Rong ^{[1
]}

Liu, Yu ^{[1
]}

机构：

[1] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 13期

基金：

中国国家自然科学基金;

关键词：

DOEBNER-VON MILLER; BIOLOGICAL EVALUATION; EFFICIENT; DERIVATIVES; ACCESS;

D O I：

10.1021/acs.joc.4c03121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinolines, a significant part of nitrogen-containing heterocycles, are widely found in functional compounds. Herin, a photochemical radical cyclization reaction of o-vinylaryl isocyanides and aryldiazonium tetrafluoroborates, has been reported to build 2,4-diaryl quinolines. Readily accessible aryl diazonium salts were utilized as aryl radical precursors at room temperature. This approach allowed good functional group tolerance and substrate applicability.

引用

页码：4571 / 4579

页数：9

共 22 条

[1] Photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access 2,4-disubstituted quinolines
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