Tailoring Design of Microneedles for Drug Delivery and Biosensing

被引：1
|
作者：
Lin, Yuexi [1 ,2 ]
Dervisevic, Muamer [1 ,2 ]
Yoh, Hao Zhe [1 ]
Guo, Keying [1 ,3 ,4 ]
Voelcker, Nicolas H. [1 ,2 ,5 ]
机构：
[1] Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville, Vic 3052, Australia
[2] Melbourne Ctr Nanofabricat, Victorian Node Australian Natl Fabricat Facil, Clayton, Vic 3168, Australia
[3] Guangdong Technion Israel Inst Technol, Fac Biotechnol & Food Engn, Shantou 515063, Peoples R China
[4] Guangdong Technion Israel Inst Technol, Guangdong Prov Key Lab Mat & Technol Energy Conver, Shantou 515063, Peoples R China
[5] Monash Univ, Mat Sci & Engn, Clayton, Vic 3168, Australia
来源：
MOLECULAR PHARMACEUTICS | 2025年 / 22卷 / 02期
基金：
澳大利亚研究理事会;
关键词：
microneedles; microfabrication; drug delivery; biosensors; theranostics; SELF-ASSEMBLED MONOLAYERS; POLYMERIC MICRONEEDLES; TRANSDERMAL DELIVERY; DRAWING LITHOGRAPHY; ARRAY PATCH; IN-VIVO; FABRICATION; SKIN; NANOPARTICLES; PENETRATION;
D O I：
10.1021/acs.molpharmaceut.4c01266
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain and customizable designs, making them suitable for personalized medicine. Understanding the key design parameters and the challenges during contact with biofluids is crucial to optimizing their use across applications. This review summarizes the current fabrication techniques and design considerations tailored to meet the distinct requirements for drug delivery and biosensing applications. We further underscore the current state of theranostic MNs that integrate drug delivery and biosensing and propose future directions for advancing MNs toward clinical use.
引用
收藏
页码：678 / 707
页数：30
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