Response to electroconvulsive therapy is associated with a more diverse oral microbiome- a prospective longitudinal cohort pilot study

被引：0
作者：
Ammer-Herrmenau, Christoph [1 ]
Hamm, Jacob [1 ]
Neesse, Albrecht [1 ]
Guenther, Kilian [2 ]
Besse, Matthias [2 ]
Zilles-Wegner, David [2 ]
机构：
[1] Univ Med Ctr Gottingen, Dept Gastroenterol Gastrointestinal Oncol & Endocr, Gottingen, Germany
[2] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Von Siebold Str 5, D-37075 Gottingen, Germany
来源：
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2025年
关键词：
Electroconvulsive therapy; Treatment resistance; Depression; Oral microbiome; Oxford nanopore technologies; DEPRESSION;
D O I：
10.1007/s00406-025-01976-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recently it has been shown that psychiatric disorders are associated with changes in the host microbiome. Little is known about the association of electroconvulsive therapy (ECT) and microbiome alterations. In our pilot-study, 15 patients with severe or treatment resistant depression were prospectively recruited and oral swabs were collected pre- and post-ECT. Compared to a control group, ECT did not lead to a significant microbial shift in longitudinal samples (p = 0.65). However, alpha diversity measurements significantly differed between responders and non-responders before ECT (observed species p = 0.014, Shannon p = 0.03) and after ECT (observed species p = 0.015, Shannon p = 0.13).
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页数：8
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