Macrophage Polarization in the Osteoarthritis Pathogenesis and Treatment

被引:9
作者
Zou, Xiongfei [1 ]
Xu, Hongjun [1 ]
Qian, Wenwei [1 ]
机构
[1] Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
macrophages; osteoarthritis; pathogenesis; polarization; progression; treatment; MESENCHYMAL STEM-CELLS; CARTILAGE REPAIR; ATTENUATES OSTEOARTHRITIS; TERT-BUTYLHYDROQUINONE; ACTIVATED MACROPHAGES; IN-VITRO; INFLAMMATION; M2; M1; APOPTOSIS;
D O I
10.1111/os.14302
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Osteoarthritis (OA) is a prevalent degenerative disorder that severely impacts quality of life due to pain and disability. Although the pathophysiology of OA remains incompletely understood, recent research highlights the role of synovial inflammation in OA onset and progression, driven primarily by inflammatory infiltrates, especially macrophages, in the synovium. These macrophages respond to the local microenvironment, polarizing into either pro-inflammatory (M1) or anti-inflammatory (M2) subtypes. This review focuses on the role of macrophage polarization in OA pathogenesis and treatment, emphasizing how M1/M2 polarization is influenced by pathways such as STAT, NF-kappa B, caspase, and MAPK. These pathways induce low-grade inflammation within OA-affected joints, altering chondrocyte metabolism, inhibiting cartilage repair, and impairing mesenchymal stem cell chondrogenesis, thereby contributing to OA progression. Additionally, this review discusses potential therapies targeting macrophage polarization, encompassing compounds, proteins, cells, and microRNAs, to offer insights into novel treatment strategies for OA.
引用
收藏
页码:22 / 35
页数:14
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