Sauchinone inhibits the growth and epithelial-mesenchymal transition of ovarian cancer cells

被引：0

作者：

Li, Na ^{[1
]}

Cui, Yujie ^{[2
]}

Wang, Xian ^{[3
]}

Li, Yucheng ^{[4
]}

机构：

[1] Peoples Hosp Lixia Dist Jinan, Dept Tradit Chinese Med, Jinan 250014, Shandong, Peoples R China

[2] Peoples Hosp Lixia Dist Jinan, Dept Obstet & Gynecol, Jinan 250014, Shandong, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Gynaecol, Jinan 250014, Shandong, Peoples R China

[4] Jinan Changru Tradit Chinese Med Clin Co Ltd, Dept Tradit Chinese Med, Huaiyin Changru Taiyuan Tang Zhixing Tradit Chines, Jinan 250000, Shandong, Peoples R China

来源：

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | 2024年 / 45卷 / 06期

关键词：

Sauchinone; Ovarian cancer; Epithelial-mesenchymal transition; Wnt//3-catenin path- way; METASTASIS; PROLIFERATION; EMT;

D O I：

10.22514/ejgo.2024.133

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ovarian cancer (OC) is a common malignant reproductive tumor among women that adversely affects their health. It has been proven that Sauchinone (Sau) derived from Saururus chinensis (Lour.) Baill may aid tumorigenesis in diversiform cancers. Despite this, the regulatory impact of Sau on OC progression remains unclear. In this study, firstly, Sau (10 or 20 mu M) had been confirmed to possess no cytotoxicity, so Sau (10 or 20 mu M) was utilized for the next experiments. Sau was shown to prevent cell growth in OC. Furthermore, Sau inhibited cell migration and invasion in OC. Our findings demonstrated that Sau attenuated the epithelial-mesenchymal transition (EMT) process by elevating E-cadherin and declining N-cadherin and alpha-smooth muscle actin (alpha-SMA) expressions. Lastly, Sau blocked the wingless/integrated (Wnt)//3catenin pathway. In summary, Sau inhibited cell growth, EMT, and blocked the Wnt//3catenin pathway in OC progression. Sau may offer novel perspectives on OC treatment in this study.

引用

页码：190 / 196

页数：7