Synergistic Effects of Probiotics and Lifestyle Interventions on Intestinal Microbiota Composition and Clinical Outcomes in Obese Adults

被引：0
作者：
Florencio, Glauber Pimentel [1 ]
Xavier, Analicy Rodrigues [1 ]
de Castro Natal, Ana Catarina [1 ]
Sadoyama, Lorena Prado [1 ]
de Brito Roder, Denise Von Dolinger [1 ]
Menezes, Ralciane de Paula [2 ]
Leal, Geraldo Sadoyama [3 ]
Patrizzi, Lislei Jorge [4 ]
Pena, Georgia das Gracas [1 ]
机构：
[1] Univ Fed Uberlandia, Sch Med, BR-38405320 Uberlandia, MG, Brazil
[2] Univ Fed Uberlandia, Inst Biomed Sci, BR-38405318 Uberlandia, MG, Brazil
[3] Fed Univ Catalao, Inst Biotechnol, BR-75704020 Catalao, GO, Brazil
[4] Univ Fed Triangulo Mineiro, Dept Physiotherapy, BR-38025350 Uberaba, MG, Brazil
来源：
METABOLITES | 2025年 / 15卷 / 02期
关键词：
intestinal microbiota; probiotics; obesity; lifestyle habits; weight loss; HUMAN GUT MICROBIOME; SLEEP-APNEA SYNDROME; WEIGHT-LOSS; METABOLISM; STRATEGIES; METAANALYSIS; EXPRESSION; SCALE; INDEX;
D O I：
10.3390/metabo15020070
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background and objective: Obesity is a growing global epidemic. The composition of the intestinal microbiota can be influenced by several factors. Studies highlight the role of intestinal bacteria in the pathophysiology of obesity. So, the objective of this study was to investigate whether the use of probiotics, together with healthy lifestyle habits, contributes to weight reduction in obese individuals by analyzing the intestinal microbiota profile. Methods: A prospective study was carried out with 45 adults with obesity. Participants underwent guidance on healthy lifestyle habits, received a probiotic component containing different microbiological strains and were followed for 60 days. Clinical parameters, body composition, biochemical analysis, and intestinal microbiota assessment were performed before and after treatment. After 60 days, it was observed that the bacterial strains present in the probiotic were present in the patients' intestinal microbiota. Participants also showed improvements in physical activity, sleep quality, and anxiety management, as well as changes in some eating habits, such as a reduction in the consumption of processed foods and a significant increase in water intake. Results: A reduction in BMI, fasting glucose, insulin, HOMA-IR, LDL cholesterol, and triglycerides was observed, in addition to an increase in HDL cholesterol, improvement in bowel movement frequency, and stool consistency. Analysis of the intestinal microbiota revealed an increase in microbial diversity and a better balance between the bacterial phyla Firmicutes and Bacteroidetes. Conclusions: The changes related to improving the composition of the intestinal microbiota, dietary habits, increased physical activity, reduced anxiety, and better sleep quality have significantly contributed to weight loss and improvements in physiological parameters in obese individuals.
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页数：26
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