Extramedullary disease in Waldenström macroglobulinemia: A population-based observational study

被引：1

作者：

Ostergaard, Simon ^{[1
,2
]}

Munksgaard, Lars ^{[2
,3
]}

Nielsen, Torsten Holm ^{[3
,4
,5
]}

Hammer, Troels ^{[4
]}

Pedersen, Lars Moller ^{[2
,3
]}

Pedersen, Mette olgod ^{[1
,2
]}

Gjerdrum, Lise Mette Rahbek ^{[1
,2
]}

机构：

[1] Zealand Univ Hosp, Dept Pathol, Roskilde, Denmark

[2] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[3] Zealand Univ Hosp, Dept Hematol, Roskilde, Denmark

[4] Copenhagen Univ Hosp, Rigshospitalet, Dept Hematol, Copenhagen, Denmark

[5] Danish Med Agcy, Copenhagen, Denmark

来源：

EJHAEM | 2024年 / 5卷 / 06期

关键词：

extramedullary; extranodal; lymphoplasmacytic lymphoma; prognosis; Waldenstr & ouml; m macroglobulinemia; WALDENSTROM MACROGLOBULINEMIA; MUTATIONS; CXCR4; MYD88;

D O I：

10.1002/jha2.1037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Extramedullary disease (EMD) is a rare manifestation of Waldenstr & ouml;m macroglobulinemia (WM), and its clinical and prognostic implications are poorly understood. Methods: In this single-center study, we investigated the clinical significance of EMD in a cohort of 469 WM patients. Results: EMD was identified in 30 (6.4%) patients, with the central nervous system, kidneys, and lungs being the most frequently affected sites. The cumulative incidence of EMD was 12.6% at 15 years. Median overall survival rates at 5 and 10 years for patients with EMD were 63% and 37%, respectively. Conclusion: Our findings indicate a persistent risk of EMD throughout the disease course, with no significant impact on long-term survival.

引用

页码：1269 / 1273

页数：5

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