ATP ion channel-type P2X purinergic receptors as a key regulatory molecule in breast cancer progression

被引：1

作者：

Nie, Xin-Hua ^{[1
]}

Li, Teng-Zheng ^{[1
]}

Peng, Cheng-Ming ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Gastroenterol, Nanchang, Jiangxi, Peoples R China

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2025年 / 267卷

关键词：

P2X purinergic receptors; Breast cancer; ATP; Antagonist; CELL INVASION; ACTIVATION; EXPRESSION; NUCLEOTIDES; MIGRATION; INCREASES; AKT;

D O I：

10.1016/j.prp.2025.155844

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Studies have confirmed that ATP ion channel P2X purinergic receptors play a key role in tumor growth and metastasis. Similarly, P2X purinergic receptors can be used as a favorable regulatory molecule of breast cancer cells to participate in the progression of breast cancer. There are abundant ATP and its cleavage products in breast cancer microenvironment, which can be used as natural activators of P2X purinergic receptors. P2X purinergic receptors play a role in regulating the growth and metastasis of breast cancer cells by mediating signal transduction, growth regulation and immune cell activity in microenvironment. However, the application of P2X purinergic receptors antagonist has the pharmacological characteristics of inhibiting the progression of breast cancer cells. Among P2X purinergic receptors, there is a close relationship between P2X7 receptor and breast cancer patients. P2X purinergic receptors can be used as a biological marker for breast cancer patients. In this paper, we discuss the functional role and regulatory molecular mechanism of P2X purinergic receptors in the progression of breast cancer. The pharmacological effects of P2X purinergic receptors selective antagonist on the growth, metastasis and invasion of breast cancer cells were further discussed. Therefore, P2X purinergic receptors can be used as a key regulatory molecule of breast cancer and a pharmacological target for potential therapy.

引用

页数：8