Insights and Interventions in Age-Associated Inflammation

被引：1

作者：

Huang, Haoyan ^{[1
]}

Ren, Jie ^{[2
,3
,4
,5
,6
,7
,8
]}

Liu, Guang-Hui ^{[1
,5
,6
,9
,10
]}

机构：

[1] Capital Med Univ, Natl Clin Res Ctr Geriatr Disorders, Aging Translat Med Ctr, Int Ctr Aging & Canc,Xuanwu Hosp, Beijing 100053, Peoples R China

[2] Chinese Acad Sci, Key Lab RNA Sci & Engn, Beijing 100101, Peoples R China

[3] China Natl Ctr Bioinformat, Beijing 100101, Peoples R China

[4] Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[6] Aging Biomarker Consortium ABC, Beijing 100101, Peoples R China

[7] Univ Chinese Acad Sci, Sino Danish Coll, Beijing 101408, Peoples R China

[8] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

[9] Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China

[10] Chinese Acad Sci, Inst Zool, Key Lab Organ Regenerat & Reconstruct, State Key Lab Membrane Biol, Beijing 100101, Peoples R China

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2025年 / 91卷

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

SENESCENCE; LANDSCAPE;

D O I：

10.1016/j.gde.2024.102306

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a systemic, complex, and heterogeneous process characterized by a progressive decline in physiological functions, rendering it a major risk factor for various chronic diseases. Chronic inflammation has emerged as both a hallmark and a driver in this complicated process. This persistent inflammatory state arises from a spectrum of stimuli, ranging from external pathogens to internal cellular remnants, to metabolic dysregulation, and to chronic stress. Here, we examine recent mechanistic advances into the driving forces behind age-related chronic inflammation, explore promising anti-inflammatory strategies to mitigate aging, and address current challenges, proposing future directions to propel this evolving field toward translational breakthrough.

引用

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