Insights and Interventions in Age-Associated Inflammation

被引：1

作者：

Huang, Haoyan ^{[1
]}

Ren, Jie ^{[2
,3
,4
,5
,6
,7
,8
]}

Liu, Guang-Hui ^{[1
,5
,6
,9
,10
]}

机构：

[1] Capital Med Univ, Natl Clin Res Ctr Geriatr Disorders, Aging Translat Med Ctr, Int Ctr Aging & Canc,Xuanwu Hosp, Beijing 100053, Peoples R China

[2] Chinese Acad Sci, Key Lab RNA Sci & Engn, Beijing 100101, Peoples R China

[3] China Natl Ctr Bioinformat, Beijing 100101, Peoples R China

[4] Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[6] Aging Biomarker Consortium ABC, Beijing 100101, Peoples R China

[7] Univ Chinese Acad Sci, Sino Danish Coll, Beijing 101408, Peoples R China

[8] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

[9] Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China

[10] Chinese Acad Sci, Inst Zool, Key Lab Organ Regenerat & Reconstruct, State Key Lab Membrane Biol, Beijing 100101, Peoples R China

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2025年 / 91卷

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

SENESCENCE; LANDSCAPE;

D O I：

10.1016/j.gde.2024.102306

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a systemic, complex, and heterogeneous process characterized by a progressive decline in physiological functions, rendering it a major risk factor for various chronic diseases. Chronic inflammation has emerged as both a hallmark and a driver in this complicated process. This persistent inflammatory state arises from a spectrum of stimuli, ranging from external pathogens to internal cellular remnants, to metabolic dysregulation, and to chronic stress. Here, we examine recent mechanistic advances into the driving forces behind age-related chronic inflammation, explore promising anti-inflammatory strategies to mitigate aging, and address current challenges, proposing future directions to propel this evolving field toward translational breakthrough.

引用

页数：14

共 80 条

[1] cGAS in action: Expanding roles in immunity and inflammation [J].

Ablasser, Andrea ;

Chen, Zhijian J. .

SCIENCE, 2019, 363 (6431) :1055-+

[2] Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment [J].

Ahmad, Sareer ;

Khan, Amjad ;

Ali, Waqar ;

Jo, Myeung Hoon ;

Park, Junsung ;

Ikram, Muhammad ;

Kim, Myeong Ok .

FRONTIERS IN PHARMACOLOGY, 2021, 12

[3] Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction [J].

Amor, Corina ;

Fernandez-Maestre, Ines ;

Chowdhury, Saria ;

Ho, Yu-Jui ;

Nadella, Sandeep ;

Graham, Courtenay ;

Carrasco, Sebastian E. ;

Nnuji-John, Emmanuella ;

Feucht, Judith ;

Hinterleitner, Clemens ;

Barthet, Valentin J. A. ;

Boyer, Jacob A. ;

Mezzadra, Riccardo ;

Wereski, Matthew G. ;

Tuveson, David A. ;

Levine, Ross L. ;

Jones, Lee W. ;

Sadelain, Michel ;

Lowe, Scott W. .

NATURE AGING, 2024, 4 (03) :336-349

[4] Chronic inflammation and the hallmarks of aging [J].

Baechle, Jordan J. ;

Chen, Nan ;

Makhijani, Priya ;

Winer, Shawn ;

Furman, David ;

Winer, Daniel A. .

MOLECULAR METABOLISM, 2023, 74

[5] Biomarkers of aging [J].

Bao, Hainan ;

Cao, Jiani ;

Chen, Mengting ;

Chen, Min ;

Chen, Wei ;

Chen, Xiao ;

Chen, Yanhao ;

Chen, Yu ;

Chen, Yutian ;

Chen, Zhiyang ;

Chhetri, Jagadish K. ;

Ding, Yingjie ;

Feng, Junlin ;

Guo, Jun ;

Guo, Mengmeng ;

He, Chuting ;

Jia, Yujuan ;

Jiang, Haiping ;

Jing, Ying ;

Li, Dingfeng ;

Li, Jiaming ;

Li, Jingyi ;

Liang, Qinhao ;

Liang, Rui ;

Liu, Feng ;

Liu, Xiaoqian ;

Liu, Zuojun ;

Luo, Oscar Junhong ;

Lv, Jianwei ;

Ma, Jingyi ;

Mao, Kehang ;

Nie, Jiawei ;

Qiao, Xinhua ;

Sun, Xinpei ;

Tang, Xiaoqiang ;

Wang, Jianfang ;

Wang, Qiaoran ;

Wang, Siyuan ;

Wang, Xuan ;

Wang, Yaning ;

Wang, Yuhan ;

Wu, Rimo ;

Xia, Kai ;

Xiao, Fu-Hui ;

Xu, Lingyan ;

Xu, Yingying ;

Yan, Haoteng ;

Yang, Liang ;

Yang, Ruici ;

Yang, Yuanxin .

SCIENCE CHINA-LIFE SCIENCES, 2023, 66 (5) :893-1066

[6] Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice [J].

Barcena, Clea ;

Valdes-Mas, Rafael ;

Mayoral, Pablo ;

Garabaya, Cecilia ;

Durand, Sylvere ;

Rodriguez, Francisco ;

Teresa Fernandez-Garcia, Maria ;

Salazar, Nuria ;

Nogacka, Alicja M. ;

Garatachea, Nuria ;

Bossut, Noelie ;

Aprahamian, Fanny ;

Lucia, Alejandro ;

Kroemer, Guido ;

Freije, Jose M. P. ;

Quiros, Pedro M. ;

Lopez-Otin, Carlos .

NATURE MEDICINE, 2019, 25 (08) :1234-+

[7] Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation [J].

Bharath, Leena P. ;

Agrawal, Madhur ;

McCambridge, Grace ;

Nicholas, Dequina A. ;

Hasturk, Hatice ;

Liu, Jing ;

Jiang, Kai ;

Liu, Rui ;

Guo, Zhenheng ;

Deeney, Jude ;

Apovian, Caroline M. ;

Snyder-Cappione, Jennifer ;

Hawk, Gregory S. ;

Fleeman, Rebecca M. ;

Pihl, Riley M. F. ;

Thompson, Katherine ;

Belkina, Anna C. ;

Cui, Licong ;

Proctor, Elizabeth A. ;

Kern, Philip A. ;

Nikolajczyk, Barbara S. .

CELL METABOLISM, 2020, 32 (01) :44-+

[8] The sirtuin-associated human senescence program converges on the activation of PAPPA [J].

Bi, Shijia ;

Jiang, Xiaoyu ;

Ji, Qianzhao ;

Wang, Zehua ;

Ren, Jie ;

Wang, Si ;

Yu, Yang ;

Wang, Ruoqi ;

Liu, Zunpeng ;

Liu, Junhang ;

Hu, Jianli ;

Sun, Guoqiang ;

Wu, Zeming ;

Diao, Zhiqing ;

Li, Jingyi ;

Sun, Liang ;

Belmonte, Juan Carlos Izpisua ;

Zhang, Weiqi ;

Liu, Guang-Hui ;

Qu, Jing .

DEVELOPMENTAL CELL, 2024, 59 (08) :991-1009.e12

[9] PKM2 aggregation drives metabolism reprograming during aging process [J].

Bie, Juntao ;

Li, Ridong ;

Li, Yutong ;

Song, Chen ;

Chen, Zhaoming ;

Zhang, Tianzhuo ;

Tang, Zhiheng ;

Su, Li ;

Zhu, Liangyi ;

Wang, Jiaxin ;

Wan, You ;

Chen, Jun ;

Liu, Xiaoyun ;

Li, Tingting ;

Luo, Jianyuan .

NATURE COMMUNICATIONS, 2024, 15 (01)

[10] Microglia in Brain Development, Homeostasis, and Neurodegeneration [J].

Bohlen, Christopher J. ;

Friedman, Brad A. ;

Dejanovic, Borislav ;

Sheng, Morgan .

ANNUAL REVIEW OF GENETICS, VOL 53, 2019, 53 :263-288

← 1 2 3 4 5 6 7 8 →