Neuroinflammation-mediated white matter injury in Parkinson's disease and potential therapeutic strategies targeting NLRP3 inflammasome

被引:1
作者
Xiao, Linglong [1 ]
Wang, Mengqi [1 ]
Shi, Yifeng [2 ]
Huang, Xinyuejia [1 ]
Zhang, Wei [1 ]
Wu, Yang [1 ]
Deng, Hao [1 ]
Xiong, Botao [1 ]
Pan, Wei [1 ]
Zhang, Jie [3 ]
Wang, Wei [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Neurosurg, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China
[2] Kunming Univ Sci & Technol, Peoples Hosp 1, Dept Neurosurg, Affiliated Hosp, Kunming 650032, Peoples R China
[3] Sichuan Univ, Core Facil West China Hosp, Chengdu, Peoples R China
关键词
Parkinson's disease; Neuroinflammation; NLRP3; inflammasome; White matter injury; Neuromodulation; SPINAL-CORD DEGENERATION; ALPHA-SYNUCLEIN; SUBSTANTIA-NIGRA; AMYLOID FIBRILS; MOTOR-NEURONS; BRAIN-INJURY; MOUSE MODEL; ACTIVATION; MICROGLIA; CELL;
D O I
10.1016/j.intimp.2024.113483
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, severely affecting the quality of life of patients. Recent studies have shown that white matter (WM) plays a vital role in higher neurological functions such as behavior and cognition. In PD patients, neurodegeneration occurs not only in neuronal soma, but also in WM fiber bundles, which are composed of neural axons. The clinical symptoms of PD patients are related not only to the degeneration of neuronal soma, but also to the degeneration of WM. Most previous studies have focused on neuronal soma in substantia nigra (SN), while WM injury (WMI) in PD has been less studied. Moreover, most previous studies have focused on intracerebral lesions in PD, while less attention has been paid to the spinal cord distal to the brain. The above-mentioned factors may be one of the reasons for the poor treatment of previous drug outcomes. Neuroinflammation has been shown to exert a significant effect on the pathological process of brain and spinal cord neurodegeneration in PD. The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome has been shown to activate and mediate neuroinflammation and exacerbate neurodegeneration in PD. NLRP3 inflammasome inhibition may be a potential strategy for the treatment of WMI in PD. This review summarizes recent advances and future directions regarding neuroinflammation-mediated WMI in PD and potential therapeutic strategies for targeting NLRP3 inflammasome in the brain and spinal cord, providing new insights for researchers to develop more effective therapeutic approaches for PD patients.
引用
收藏
页数:12
相关论文
共 50 条
  • [41] The Potential of NLRP3 Inflammasome as a Therapeutic Target in Neurological Diseases
    He, Wenfang
    Hu, Zhiping
    Zhong, Yanjun
    Wu, Chenfang
    Li, Jinxiu
    MOLECULAR NEUROBIOLOGY, 2023, 60 (05) : 2520 - 2538
  • [42] A novel strategy for bioactive natural products targeting NLRP3 inflammasome in Alzheimer's disease
    Yang, Zhiyou
    Liu, Junxin
    Wei, Shuai
    Deng, Jiahang
    Feng, Xinyue
    Liu, Shucheng
    Liu, Mingxin
    FRONTIERS IN PHARMACOLOGY, 2023, 13
  • [43] New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota
    Shen, Heping
    Guan, Qiaobing
    Zhang, Xiaoling
    Yuan, Chao
    Tan, Zhengye
    Zhai, Liping
    Hao, Yanan
    Gu, Yanling
    Han, Chenyang
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2020, 100
  • [44] Therapeutic role of NLRP3 inflammasome inhibitors against Alzheimer's disease
    Tantra, Tanmoy
    Rahaman, T. A. Abdul
    Nandini
    Chaudhary, Sandeep
    BIOORGANIC CHEMISTRY, 2024, 153
  • [45] A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease
    Huang, Shuxuan
    Chen, Zhi
    Fan, Binglin
    Chen, Yuan
    Zhou, Liyuan
    Jiang, Bingjian
    Long, Haiyin
    Zhong, Weizhang
    Li, Xiaofeng
    Li, Yanhua
    JOURNAL OF NEUROIMMUNOLOGY, 2021, 354
  • [46] Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease
    Chen, Qiu-Ling
    Yin, Hao-Ran
    He, Qing-Yu
    Wang, Ying
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 138
  • [47] Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis
    Cai, Yawen
    Chai, Yuhui
    Fu, Yu
    Wang, Yingdi
    Zhang, Yiming
    Zhang, Xue
    Zhu, Lingpeng
    Miao, Mingxing
    Yan, Tianhua
    FRONTIERS IN AGING NEUROSCIENCE, 2022, 13
  • [48] Mechanism of effect and therapeutic potential of NLRP3 inflammasome in spinal cord injury
    Gu, Hou-yun
    Liu, Ning
    EXPERIMENTAL NEUROLOGY, 2025, 384
  • [49] The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target
    William T. O’Brien
    Louise Pham
    Georgia F. Symons
    Mastura Monif
    Sandy R. Shultz
    Stuart J. McDonald
    Journal of Neuroinflammation, 17
  • [50] Therapeutic Potential of Pharmacological Targeting NLRP3 Inflammasome Complex in Cancer
    Tezcan, Gulcin
    Garanina, Ekaterina E.
    Alsaadi, Mohammad
    Gilazieva, Zarema E.
    Martinova, Ekaterina, V
    Markelova, Maria, I
    Arkhipova, Svetlana S.
    Hamza, Shaimaa
    McIntyre, Alan
    Rizvanov, Albert A.
    Khaiboullina, Svetlana F.
    FRONTIERS IN IMMUNOLOGY, 2021, 11