Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery

被引:0
作者
Titkare, Nikhil [1 ]
Chaturvedi, Sachin [1 ]
Borah, Sapan [2 ]
Sharma, Nitish [1 ]
机构
[1] Govt India, Natl Inst Pharmaceut Educ & Res Ahmedabad NIPER A, Dept Pharmaceut Anal, Gandhinagar, Gujarat, India
[2] Govt India, Natl Inst Pharmaceut Educ & Res Ahmedabad NIPER A, Dept Biotechnol, Gandhinagar, Gujarat, India
关键词
biomarker; disease; mass spectrometry; metabolomics; ION MOBILITY; STRUCTURAL-CHARACTERIZATION; CHROMATOGRAPHY; SERUM; IDENTIFICATION; URINE; MS; PLASMA; QUANTIFICATION; FUNDAMENTALS;
D O I
10.1002/bmc.6019
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Mass spectrometry (MS) plays a crucial role in metabolomics, especially in the discovery of disease biomarkers. This review outlines strategies for identifying metabolites, emphasizing precise and detailed use of MS techniques. It explores various methods for quantification, discusses challenges encountered, and examines recent breakthroughs in biomarker discovery. In the field of diagnostics, MS has revolutionized approaches by enabling a deeper understanding of tissue-specific metabolic changes associated with disease. The reliability of results is ensured through robust experimental design and stringent system suitability criteria. In the past, data quality, standardization, and reproducibility were often overlooked despite their significant impact on MS-based metabolomics. Progress in this field heavily depends on continuous training and education. The review also highlights the emergence of innovative MS technologies and methodologies. MS has the potential to transform our understanding of metabolic landscapes, which is crucial for disease biomarker discovery. This article serves as an invaluable resource for researchers in metabolomics, presenting fresh perspectives and advancements that propels the field forward.
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收藏
页数:23
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