Perioperative Neurocognitive Disorder in Individuals with a History of Traumatic Brain Injury: Protocol for a Systematic Review and Meta-Analysis

被引：0
作者：
Khan, Zeeshan Ahmad [1 ]
Sumsuzzman, Dewan Md. [2 ]
Duran, Tahiris A. [1 ]
Ju, Ling-Sha [1 ]
Seubert, Christoph N. [1 ]
Martynyuk, Anatoly E. [1 ,3 ]
机构：
[1] Univ Florida, Coll Med, Dept Anesthesiol, JHMHC, 1600 SW Archer Rd, Gainesville, FL 32610 USA
[2] York Univ, Agent Based Modelling Lab, Toronto, ON M3J 1P3, Canada
[3] Univ Florida, McKnight Brain Inst, Coll Med, Gainesville, FL 32611 USA
来源：
BIOLOGY-BASEL | 2025年 / 14卷 / 02期
基金：
美国国家卫生研究院;
关键词：
general anesthetics; inflammation; meta-analysis; perioperative neurocognitive disorder; traumatic brain injury; OUTCOME MEASURES; RECOMMENDATIONS; CHILDREN; PARENTS; STRESS;
D O I：
10.3390/biology14020197
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Postoperative neurocognitive disorder (PND) is a cognitive decline after general anesthesia and surgery, influenced by preexisting neurodegenerative conditions, stress, and inflammation. Traumatic brain injury (TBI) is linked to a dysregulated stress response, neuroinflammation, and cognitive issues. Patients with TBI often need extracranial surgeries under general anesthesia (GA), which can increase stress, neuroinflammation, and neurodegenerative changes, raising PND risk. We will search databases like Ovid Medline and Embase for studies on cognitive function in patients with mild to moderate TBI who had extracranial surgeries under general anesthesia (GA). Screening and data extraction will be done manually and with AI-assisted tools (ASReview). Study quality will be assessed using the Newcastle-Ottawa Scale. Statistical analyses will include mean differences, odds ratios, and meta-regression, addressing heterogeneity, sensitivity, and publication bias using Stata/SE. By meta-analyzing clinical studies, we aim to determine if TBI and GA/surgery interact to induce PND. We will use various data sources, subgroup analyses, sensitivity analyses, and meta-regression to assess factors like age, gender, and type of GA/surgery. This meta-analysis will enhance our understanding of PND risks, inform clinical practices, and highlight new research directions. The systematic review is registered in PROSPERO (CRD42024510980).
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页数：8
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