Potential Antioxidant and Anti-inflammatory Effects of Astaxanthin Ionic Liquid Liposomes

被引：3
作者：
Lu, Beibei [1 ,2 ,3 ,4 ,5 ]
Ruan, Bo [6 ]
Zhang, Jianglin [2 ,3 ]
Zhang, Jiaheng [4 ,5 ]
Liang, Yanzhen [7 ]
机构：
[1] Guangzhou Huali Coll, Sch Pharm, Guangzhou 511325, Peoples R China
[2] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Dermatol, Shenzhen 518020, Guangdong, Peoples R China
[3] Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
[4] Harbin Inst Technol Shenzhen, Sauvage Lab Smart Mat, Shenzhen 518055, Peoples R China
[5] Harbin Inst Technol Shenzhen, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
[6] Shenzhen Shinehigh Innovat Technol Co Ltd, Shenzhen 518055, Peoples R China
[7] Shangya Guangzhou Biogene Technol Co Ltd, Guangzhou 510440, Peoples R China
来源：
ACS APPLIED BIO MATERIALS | 2025年 / 8卷 / 04期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
ionic liquid; liposome; astaxanthin; antioxidant; anti-inflammatory; DELIVERY;
D O I：
10.1021/acsabm.4c01889
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Astaxanthin is an antioxidant with extremely high antioxidant activity. However, the stability and solubility of free astaxanthin are poor. Therefore, we prepared astaxanthin-betaine (ASTA-Bet) ionic liquid liposomes through a combination of theoretical calculations and experimental research and studied their physicochemical properties and biological effects. This liposome has good stability and skin permeability. The cumulative permeability of the ASTA-Bet ionic liquid liposome is 22.95 times that of free astaxanthin and 2.41 times that of the ASTA-Bet ionic liquid. The particle size of astaxanthin liposomes was 117.2 nm, and the particle size did not change significantly after 28 days of storage, indicating good stability. Compared with free astaxanthin, the ASTA-Bet ionic liquid liposome has good antioxidant activity and can exert antioxidant and anti-inflammatory effects by regulating the TGF-beta 1/smad2/smad3 pathway damaged by ultraviolet radiation, which may contribute to the resistance to ultraviolet radiation damage. Therefore, it can be used as a raw material to develop cosmetics with antiaging and anti-inflammatory functions.
引用
收藏
页码：3052 / 3060
页数：9
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