Protective effects of Pelargonium graveolens (geranium) oil against cefotaxime-induced hepato-renal toxicity in rats

被引:0
|
作者
Azzam, Shaimaa M. [1 ,10 ]
Elsanhory, Heba M. A. [2 ]
Abd El-Slam, Ahmed H. [3 ]
Diab, Marwa S. M. [4 ,10 ]
Ibrahim, Halima Mohamed [5 ,10 ]
Yousef, Abdalrahman Mohammed [3 ]
Sabry, Fatma Mahmoud [6 ,10 ]
Khojah, Ebtihal Y. [7 ]
Bokhari, Somaiah A. [8 ]
Salem, Gad Elsayed Mohamed [9 ,10 ]
Zaghloul, Marwa Saad [1 ]
机构
[1] Egyptian Drug Author EDA, Dept Biochem, Giza, Egypt
[2] Sinai Univ, Fac Pharm, Pharmacol & Toxicol Dept, El Ismailia, Egypt
[3] Al Azhar Univ, Fac Med, Dept Forens Med & Clin Toxicol, Cairo, Egypt
[4] Egyptian Drug Author EDA, Cell Biol & Histol Mol Drug Evaluat Dept, Giza, Egypt
[5] Egyptian Drug Author EDA, Dept Physiol, Giza, Egypt
[6] Egyptian Drug Author EDA, Pharmacol Dept, Giza, Egypt
[7] Taif Univ, Coll Sci, Dept Food Sci & Nutr, Taif, Saudi Arabia
[8] Matern & Children Hosp, Pharmaceut Care Dept, Mecca, Saudi Arabia
[9] Dept Microbiol Egyptian Drug Author EDA, Giza, Egypt
[10] Natl Org Drug Control & Res NODCAR, Giza, Egypt
来源
FRONTIERS IN TOXICOLOGY | 2024年 / 6卷
关键词
geranium oil; cefotaxime; hepatotoxicity; oxidative stress; antioxidant defense; MAPK; Nrf2; nephrotoxicity; ACUTE KIDNEY INJURY; OXIDATIVE STRESS; ANTIOXIDANT; AUTOPHAGY;
D O I
10.3389/ftox.2024.1489310
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Cefotaxime is a broad-spectrum antibiotic targeting Gram-negative bacteria used for diverse infections, but it can be toxic to the stomach, liver, and kidneys. This study explored the protective effects of geranium oil against cefotaxime-induced hepatotoxicity and nephrotoxicity in rats, employing biochemical, histopathological, and immunohistochemical evaluations. Thirty rats were divided into five groups of six animals each one. Group 1 received orally normal saline for 14 days, Group 2 was given orally 2.5% DMSO for 14 days, Group 3 received cefotaxime (200 mg/kg/day IM) for 14 days, Group 4 received with cefotaxime (200 mg/kg/day IM) and geranium oil (67 mg/kg b. w./day orally in DMSO) for 14 days, and Group 5 received geranium oil alone (67 mg/kg b. w./day orally in DMSO) for 14 days. Geranium oil significantly reduced cefotaxime-induced damage, evidenced by lower serum levels of liver enzymes (AST, ALT), renal markers (urea, creatinine), and other indicators (alkaline phosphatase, TNF-alpha, IL-1Beta, MAPK, nitric oxide, MDA). It also increased levels of protective tissue biomarkers such as NrF2, albumin, catalase, Beclin 1, and reduced glutathione (GSH). Histopathological and immunohistochemical analyses revealed significant protective effects in liver and renal tissues in rats treated with Geranium oil. These results suggest that Geranium oil is effective in mitigating cefotaxime-induced hepatotoxicity and renal toxicity.
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页数:17
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