The Impact of "Close Margins" in HPV-Associated Oropharyngeal Squamous Cell Carcinoma Treated with TORS

被引:0
|
作者
Calcano, Gabriela A. [1 ]
Rourk, Katelyn S. [1 ]
Routman, David M. [2 ]
O'Byrne, Jamie J. [3 ]
Chintakuntlawar, Ashish V. [4 ]
Garcia, Joaquin J. [5 ]
Price, Daniel L. [1 ]
Tasche, Kendall K. [1 ]
Moore, Eric J. [1 ]
Van Abel, Kathryn M. [1 ]
Yin, Linda X. [1 ]
机构
[1] Mayo Clin, Dept Otolaryngol Head & Neck Surg, 200 1st St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Radiat Oncol, Rochester, MN USA
[3] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA
[4] Mayo Clin, Div Hematol & Med Oncol, Phoenix, AZ USA
[5] Mayo Clin, Dept Pathol, Rochester, MN USA
关键词
close margins; locoregional recurrence; oropharynx cancer; TRANSORAL ROBOTIC SURGERY; POSITIVE MARGINS; LOCAL RECURRENCE; METAANALYSIS; THERAPY;
D O I
10.1002/ohn.1127
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
ObjectiveMargin distance is a significant prognosticator in oral cavity cancer but its role in HPV-related oropharyngeal squamous cell carcinoma [HPV(+)OPSCC] remains unclear. Here, we investigate the impact of margin distance on locoregional recurrence in HPV(+)OPSCC. Study DesignThis is a retrospective cohort study of surgically treated HPV(+)OPSCC patients. Patients received either standard of care (at least 60 Gy with or without cisplatin) or de-escalated adjuvant therapy (30-36 Gy with concurrent docetaxel). Margin distance was measured in mm from the primary specimen or in combination with separately submitted margins. Kaplan-Meier survival analysis with univariate and multivariable Cox regressions were conducted to determine the impact of margin distance on risk of local and locoregional recurrence. SettingSetting for this is 3 tertiary centers between January 2010 and February 2024. ResultsAmong 1102 included patients, 33 (3.0%) had positive final margins. 374 patients had adequate margin distance data available. Margin distance was >3 mm in 73.4%, 1 to 3 mm in 24.5%, and <1 mm in 2.2% of patients. Positive final margins, pT4 disease, pN2 disease, and surgery alone as a treatment modality (P < .02 for all) was associated with higher risk of 5-year locoregional recurrence. Margin distance did not significantly impact risk of local or locoregional recurrence even after adjusting for de-escalated adjuvant therapy (P > .05). ConclusionPositive final margins after TORS without adjuvant radiotherapy for HPV(+)OPSCC carries a high risk of local recurrence. Margin distance does not appear to significantly impact risk of local or locoregional recurrence, even after de-escalated adjuvant radiotherapy.
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页数:9
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